Under vacuum condition, the Nd, Y∶SrF2 laser crystals were annealed at high temperatures from 1060 ℃ to 1100 ℃. The X-ray double crystal rocking curve, the bending strength, the stress distribution, and the wave-front aberration spectrum of Nd, Y∶SrF2 crystals were measured before and after annealing. The results show that the crystallization properties, the bending strength, the stress distribution and the optical homogeneity of the crystals are improved by annealing at a high temperature. When the annealing temperature is 1080 ℃ and the annealing time is 36 h , the crystal is obtained with the best integrated performance, and hence the annealing temperature of 1080 ℃ and the annealing time of 36 h are the optimal annealing parameters.