Journal of Shanghai University of Sport, Volume. 49, Issue 7, 75(2025)

Research Progress on the Interaction Between Rhythmic Molecular Clock and Mitochondrial Quality Control Under the Intervention of Diet and Exercise

ZHANG Zhe1,2, QIAN Shuaiwei3, and DING Shuzhe1,2、*
Author Affiliations
  • 1Key Laboratory of Adolescent Health Assessment and Exercise Intervention of Ministry of Education, East China Normal University, Shanghai 200241, China
  • 2College of Physical Education and Health, East China Normal University, Shanghai 200241, China
  • 3Hubei Key Laboratory of Sports Training Monitoring, Wuhan Institute of Physical Education, Wuhan 430079, Hubei, China
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    Based on summing up the latest research progress of the interaction between molecular clock and mitochondrial quality under exercise and dietary change, this study proposes that intermittent fasting may promote health by regulating the molecular clock through mitophagy. The interaction between the molecular clock and the mitochondria dynamics can effectively avoid insulin resistance caused by high fat diet. In terms of sports, it has been elucidated that PGC-1α, Fis1 and HIF-1α can interact with BMAL1 in adipose tissue, liver and skeletal muscle, respectively, and exercise regulates the interaction of molecular clock and MQC through BMAL1-HIF-1α,CLOCK-mitophagy, and AMPK-SIRT1-PGC-1α. However, the mechanism of long-term chrono-aerobic/anaerobic exercise and/or different exercise intensities/modes combined with intermittent fasting to regulate the interaction effect of mitochondrial quality and rhythmic molecular clock needs further study. Mitophagy may be the important link in this process. Whether exercise ameliorates metabolic abnormalities induced by high fat diet through the interaction effect of molecular clock and mitochondrial dynamics remains to be explored.

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    ZHANG Zhe, QIAN Shuaiwei, DING Shuzhe. Research Progress on the Interaction Between Rhythmic Molecular Clock and Mitochondrial Quality Control Under the Intervention of Diet and Exercise[J]. Journal of Shanghai University of Sport, 2025, 49(7): 75

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    Paper Information

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    Received: Sep. 19, 2023

    Accepted: Aug. 25, 2025

    Published Online: Aug. 25, 2025

    The Author Email: DING Shuzhe (szding@tyxx.ecnu.edu.cn)

    DOI:10.16099/j.sus.2023.09.19.0006

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