Uncooled infrared detectors have been applied in several fields with the development of infrared imaging technology, and how their thermal effect under laser irradiation has become one of the current research directions. In this paper, the structure and working principle of VO_x imaging detector are analyzed at firstly. Then, experiments of laser irradiation VO_x uncooled IR imaging equipment under saturation and point damage by 10.6 μm pulse laser is carried out. Under laser irradiation saturation conditions, saturation occurs in the center image element of the spot, and at the end of the laser irradiation, the response of this image element increases by about 20 grey levels compared to the pre-irradiation period. The pixels around jamming spot center are abnormal corresponding, and return to normal after non-uniformity correction; under laser irradiation point damage conditions, a circular interference effect occurred, and the pixels in the center of the jamming spot show damage, which could not be recovered even with non-uniformity correction. And the corresponding laser power densities are given. Based on the experimental results, the diffraction effect is simulated, and it is pointed out that the diffraction, the thermal effect of the detector and the heat "overflow" are the reasons leading to the detector pixel anomaly larger than the irradiated spot. This paper is an important reference for the development of uncooled VO_x detectors and the study of interference effects.