In order to improve the performance of laser cladding Ni-based cladding layer on impeller surface of centrifugal pump, (Ti,W)C particles were added. The microstructure of WC hard phase and Ni base alloy was characterized, and the wear resistance was tested. The results showed that the cladding layer with dense structure is formed and the overall microstructure is uniform. The (Ti,W)C particles are partially remelted by laser with high energy density and solidified with the melted nickel-based powder. The remelted 45 steel matrix solidifies and forms a new phase. There are Fe3Ni, Cr23C6, and W2C phases on the surface of the cladding layer. The microhardness of the cladding layer is 623 HV, which is significantly higher than that of 45 steel. The friction coefficient of (Ti,W)C particle reinforced Ni-base cladding layer is 0.32, which is reduced by 47.2% compared with the matrix. Compared with 30.83 mg of 45 steel, the wear amount decreased to 9.67 mg. There are grains of different sizes on the surface of the cladding layer, and no furrow structure is formed. The wear marks contain C, Ni, W, and Cr, which can effectively protect the matrix structure and make it show better wear resistance.