Addressing the prevalent safety education issues and hazard source analysis in university chemistry laboratories, this study endeavors to establish a robust system for laboratory safety education and access permissions. The objective is to elevate the standard of laboratory safety management. A multi-tiered safety education and access permission framework has been devised, spanning from the university level to departmental levels and down to specific laboratories. This system addresses various facets, such as the differentiation of educational content, streamlining of access permission procedures, diversification of educational approaches, and professionalization of teaching staff. Additionally, measures have been proposed to enhance the safety literacy of laboratory personnel and ensure the safe and orderly operation of laboratories. These include continual enhancements to the safety education and access permission system, along with the implementation of systematic, professional, and routine safety education training.