Photon therapy has been widely used in the clinical treatment of pain diseases because of its safety, noninvasive, painless, non-invasive, non addictive, convenient operation and remarkable curative effects.?This paper introduces the research progress of low-level laser therapy, high-intensity laser therapy, semiconductor lase therapy and laser acupuncture therapy based on photon technology in pain relief.?By studying the mechanism of pain relief and clinical practice means, we can provide theoretical basis and practical guidance for the comprehensive application of photon technology in pain clinical treatment.