Optical system plays an important role in space optical communication, and optical thin-film has become the key technology of the optical components. The laser filter film is designed and fabricated aiming at four bands of laser work of 532, 808, 1064, 1550 nm, by chosing Ti3O5 and SiO2 as high and low refractive index materials. It is used the design software of film system and adopts the method of electron beam evaporation and ion assisted deposition. The transmissivity of substrate after coating film at 808 nm is better than 90%, at 532, 1064, 1550 nm, reflectance is better than 99%. It is focused on half-wave hole in 808 nm transmission area and improved the laser damage threshold of film by cleaning the substrate, reducing the absorption of the film and vacuum annealed. The laser clear filter meets the requirements of the system after a performance test and evaluation.