The Directional Multi-Spectral Camera (DMC) consists of five cameras, and the imaging is independent. This imaging method makes it difficult to ensure the consistent radiation response among multiple cameras in the process of realizing stereoscopic imaging. In order to achieve the same radiation response of each camera and each CCD, a multi-camera global chromatic aberration calibration method is proposed in this paper, and the radiation correction effect of histogram on-orbit statistics method and yaw calibration method on the Directional Multi-Spectral Camera images is compared. Compared with the correction effect between cameras, the color of the five cameras corrected by the multi-camera global color difference calibration method is closer, and the relative radiometric correction accuracy of uniform objects is higher. According to the comparison of the correction effect of CCD inter-chip images, the CCD inter-chip images corrected by histogram statistics method and multi-camera global chromatic aberration calibration method show color balance, basically no chromatic aberration, and the relative radiometric correction accuracy is basically less than 3%. In conclusion, the multi-camera global chromatic aberration calibration method is more suitable for correcting the radiation problem between multi-angle and multi-spectral cameras.