In order to optimize the Fe-Ni-Cr powder laser cladding process parameters and get the best process of microstructure and properties of cladding, laser power, scanning speed, powder feeding speed and away from the focal design of four factors three levels orthogonal test L9(43) and arrange the experiment, the surface morphology, dilution rate and microhardness as evaluation indexes, through the comprehensive scoring method to determine the best process parameters, and analyze the optimization of process under the structure morphologies of the cladding layer, microhardness and friction and wear properties. The results show that the optimal process parameters are: laser power 2 400 W, scanning speed 5 mm/s, powder feeding speed 20 g/min, defocusing capacity +5 mm; The optimal cladding layer consists of fine cellular crystals (the grain size is about 8 μm) and columnar crystals (the grain size is about 17 μm). The substrate consists of ferrite and pearlite with a grain size of 27~50 μm.The average hardness of cladding layer is 633 HV, which is 3.6 times that of substrate. The average friction coefficient of the cladding layer is 51% of the base material, and the wear loss is 37.1% of the base material, indicating that the friction reduction and wear resistance of the cladding layer are good.