The ZT1 amorphous alloy film with a thickness of 80 μm was ablated and cut in different laser (100 ns、3 ps) to study the adaptability of laser processing amorphous alloy. Results show that the thermal effect of nanosecond laser processing was obvious, typical thermal defects such as recast, crack and spatter existed, and a large range of crystallization area with special textures and colors was formed on the outside. The effect of "cold" processing was obtained by picosecond laser, and no recast, crack, spatter and crystallization were found. Under the conditions of atmosphere, multi-pulse, high laser energy density, oxidation occurred to some extent in the processing area of nanosecond and picosecond laser. The former occurred on the surface of the whole heat affected zone, while the latter only occurred in the laser irradiated zone.