Low level laser therapy (LLLT) is a new type of physical therapy that uses low level laser to irradiate relevant skin, acupoints and other parts of the human body to treat cardiovascular and cerebrovascular diseases, relieve pain, and promote healing. It can stimulate the complex IV (cytochrome c oxidase) of the mitochondrial respiratory chain and increase the synthesis of adenosine-triphosphate, reactive oxygen species, NO and other substances, helping to regulate cell behavior in a targeted manner. The hypertension, hyperglycemia and hyperlipidemia (three highs) are the most common blood diseases. The changes in various blood parameters caused by it can easily cause other organ dysfunctions. At present, the number of “three highs” disease groups is increasing, and the patients are younger, hence, there is an urgent need for a portable and effective treatment technique to deal with the disease. In recent years, studies have found that LLLT also has a significant effect on blood system diseases and can effectively reduce high blood pressure. In addition, LLLT can also adjust blood sugar and have a certain therapeutic effect on related complications caused by high blood sugar. At the same time, it can also adjust the concentration of blood lipids, whereas more applications focus on the first two. This kind of treatment has the advantage of non-invasiveness and portability, hence, it is expected to become a new treatment method. This article will review the application of LLLT in the “three highs” and related mechanisms.