International Journal of Extreme Manufacturing, Volume. 2, Issue 1, 12003(2020)

Additive manufacturing in radiation oncology: a review of clinical practice, emerging trends and research opportunities

Rance Tino1,2,3, Martin Leary1,3, Adam Yeo2, Elizabeth Kyriakou1,2, Tomas Kron2,3,4, and Milan Brandt1,3、*
Author Affiliations
  • 1RMIT Centre for Additive Manufacture, School of Engineering, RMIT University, Melbourne, Australia
  • 2Physical Sciences Department, Peter MacCallum Cancer Centre, Melbourne, Australia
  • 3ARC Industrial Transformation Training Centre in Additive Biomanufacturing, Queensland University of Technology, Brisbane, Australia
  • 4Centre for Medical Radiation Physics, University of Wollongong, Wollongong Australia
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    The additive manufacturing (AM) process plays an important role in enabling cross-disciplinary research in engineering and personalised medicine. Commercially available clinical tools currently utilised in radiotherapy are typically based on traditional manufacturing processes, often leading to non-conformal geometries, time-consuming manufacturing process and high costs. An emerging application explores the design and development of patient-specific clinical tools using AM to optimise treatment outcomes among cancer patients receiving radiation therapy. In this review, we: 1)? highlight the key advantages of AM in radiotherapy where rapid prototyping allows for patient-specific manufacture 2) explore common clinical workflows involving radiotherapy tools such as bolus, compensators, anthropomorphic phantoms, immobilisers, and brachytherapy moulds; 3) investigate how current AM processes are exploited by researchers to achieve patient tissuelike imaging and dose attenuations. Finally, significant AM research opportunities in this space are highlighted for their future advancements in radiotherapy for diagnostic and clinical research applications.


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    Rance Tino, Martin Leary, Adam Yeo, Elizabeth Kyriakou, Tomas Kron, Milan Brandt. Additive manufacturing in radiation oncology: a review of clinical practice, emerging trends and research opportunities[J]. International Journal of Extreme Manufacturing, 2020, 2(1): 12003

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    Paper Information

    Category: Topical Review

    Received: Dec. 15, 2019

    Accepted: --

    Published Online: Jun. 4, 2020

    The Author Email: Brandt Milan (



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