Aiming at the phenomenon of non-uniformity change caused by on-orbit temperature change of the high-orbit area array infrared earth sensor, an optical-mechanical implementation scheme for on-orbit non-uniformity calibration is proposed. The miniaturized, lightweight, and long-life optomechanical system includes calibration blackbody components and optical imaging systems. The system includes surface source blackbody, motion control mechanism, and optical imaging system. Based on the analysis of the necessity and mechanism of system non-uniformity correction, the relationship between the selection and design of surface source blackbody, motion control mechanism and optical system is studied, and the simulation design of each group of components is realized. Based on the simulation results, the effects and advantages of system heterogeneity calibration are analyzed and compared. The effect of the heterogeneity of the system is evaluated by using the orbiting earth imaging data, and the evaluation results show that the requirements for on-orbit application are met.