Glass-lined chemical equipment is an irreplaceable production equipment in the petrochemical and pharmaceutical industries, which is made of enamel and metal matrix by high-temperature melting. It has the dual advantages of metal strength and glass corrosion resistance and easy cleaning. However, cracks are likely to occur in service, causing the enamel to fall off, affecting the safe operation of glass-lined equipment. To solve this problem, the effect of zirconia content and particle size on fracture toughness was studied by adding zirconia during the glass-lined sintering process. The research results showed that the three-point bending performance of the glass-lined board was significantly improved when the mass fraction of zirconia addition was 2. 2 wt%, and the three-point bending performance was the best when the zirconia particle average diameter was3μm.