This paper investigates the low-cycle fatigue performance of boron-modified TC4 titanium alloy deposited via laser melting at different strain amplitudes. The results reveal that the low-cycle fatigue performance of boron-modified TC4 titanium alloy deposited via laser melting is comparable to that of annealed forging when subjected to a strain amplitude of 0.8%--1.0%. A comparison of the microstructure and low-cycle fatigue performance of the boron-modified laser melting deposited TC4 in solid solution-aging state with the annealed TC4 forging is performed. It is found that as the strain amplitude is above 1.0%, the basket-shaped microstructure of the solid solution-aged boron-modified TC4 titanium alloy deposited via laser melting exhibits better resistance to crack propagation compared with the double phase microstructure of TC4 annealed forgings. Moreover, the solid solution-aged boron-modified TC4 titanium alloy obtained via laser melting deposition exhibits different degrees of cyclic softening behavior at different strain amplitudes. Finally, the morphologies of the low-cycle fatigue fractures of solid solution-aged boron-modified TC4 titanium alloy obtained via laser melting deposition are observed under a scanning electron microscope, and crack propagation during low-cycle fatigue failure is studied here.