Laser & Optoelectronics Progress, Volume. 62, Issue 16, 1600002(2025)

Applications and Advancements of U-Net and Its Variants in Brain Tumor Image Segmentation

Nan Wang, Hua Wang, Dejian Wei, Liang Jiang, Peihong Han, and Hui Cao*
Author Affiliations
  • School of Medical Informational Engineering, Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong , China
  • show less

    Brain tumor is a serious central nervous system disease, with an increasing incidence rate that poses a significant challenge to global public health security. Due to the complexity of tumor growth site and the sensitivity and heterogeneity of surrounding tissues, treatment of brain tumors is often limited. U-Net and its variants have demonstrated excellent performance in brain tumor image segmentation and are therefore commonly used to assist in the diagnosis of brain tumors. First, this study summarizes U-Net improvement strategies for brain tumor image segmentation tasks, focusing on methods such as attention mechanisms, enhanced residuals, skip connections, and Transformer fusion, and analyzes their improvement effects on Dice coefficient, sensitivity, and specificity. Additionally, the study discusses the frontier research directions of U-Net, such as multimodal fusion, generative adversarial networks (GAN) applications, and self-supervised learning, to address the limitations of current technologies and expand the application scenarios of brain tumor image segmentation. Finally, the study explores the current challenges and issues in the field of brain tumor image segmentation and provides insights into future research directions.

    Keywords
    Tools

    Get Citation

    Copy Citation Text

    Nan Wang, Hua Wang, Dejian Wei, Liang Jiang, Peihong Han, Hui Cao. Applications and Advancements of U-Net and Its Variants in Brain Tumor Image Segmentation[J]. Laser & Optoelectronics Progress, 2025, 62(16): 1600002

    Download Citation

    EndNote(RIS)BibTexPlain Text
    Save article for my favorites
    Paper Information

    Category: Reviews

    Received: Dec. 6, 2024

    Accepted: Mar. 12, 2025

    Published Online: Aug. 8, 2025

    The Author Email: Hui Cao (caohui63@163.com)

    DOI:10.3788/LOP242385

    CSTR:32186.14.LOP242385

    Topics