In order to achieve the green environmental protection requirements of removing the bridge protective lacquer layer, the application of layer cleaning technology in the removal of paint from bridges was carried out by using the short pulse and high peak power characteristics of pulsed laser. Through the orthogonal test method, the effects of process parameters such as average power, frequency, scanning speed, number of scans and other parameters on the quality of laser cleaning, as well as the influence weight of each process parameter, and the best process parameters are obtained. The best parameters are average power 50 W, frequency 70 kHz, scan speed 300 mm/s and 1 scan. According to the optimized parameters, a good cleaning area with roughness Ra 6.6 μm and Rz 30.1 μm without paint residue is obtained, which verifies the feasibility and scalability of laser removal paint in bridge protection applications.