A series of ferroelectric thin films of Bi3.25Ce0.75Ti3O12 (BCTO) was deposited on a composite substrate of Pt/Ti/SiO2/Si through the sol-gel method, and the deposited films were irradiated with different doses of gamma rays. The crystal structure, surface morphology, ferroelectricity, leakage, and anti-fatigue properties of the deposited films before and after irradiation were compared by thermogravimetric differential scanning calorimetry (TG-DSC), X-ray diffraction (XRD), scanning electron microscope-energy dispersive spectrometer (SEM-EDS) and ferroelectric tester. The results showed that an increase in absorbed γ ray doses, didn't change the crystal structure of films. The ferroelectricity of the deposited films decreased significantly with the residual polarization 2Pr decreasing from 51.5 μC/cm2 to 23.7 μC/cm2. The leakage current density of the films increased slightly from 0.9×10-7 A/cm2 to 7.2×10-7 A/cm2. Some of the films showed fatigue performance after 1012 polarization switching cycles.

To explore the therapeutic effect of metformin combined with single high-dose radiotherapy in mice with non-small cell lung cancer and the mechanism involved. Invitro cell test: the cytotoxicity of metformin under different oxygen and glucose contents was evaluated using cell survival curves. Invivo xenograft tumor test: NSCLC-A549 cells were injected into mice, which were then divided into the following five groups: control group, metformin group, single high-dose radiotherapy group, metformin 1 h before radiotherapy group, and metformin 24 h after radiotherapy group. Growth of the tumor was evaluated in each group, and the blood flow and histology of the tumor tissues were analyzed. According to the invitro test results, metformin was the most cytotoxic under hypoxic and low-glucose conditions. The in vivo results showed that the tumor volume was the smallest in the mouse groups administered metformin 1 h before high-dose radiotherapy and 24 h after radiotherapy ((0.47±0.12) cm3 and (0.49±0.21) cm3, respectively). Blood flow analysis showed that single high-dose radiotherapy destroyed the micro-vessels of tumor tissue and reduced the perfusion of oxygen and glucose. Histological analysis revealed that cells in hypoxic and hypoglycemic area of the tumor tissue center were preferentially killed by metformin, whereas there were viable cells in the surrounding well perfused areas. Metformin combined with single high-dose radiotherapy enhanced the toxicity by changing tumor cell metabolism. These results provide theoretical and data support for the future use of metformin combined with stereotactic body radiotherapy.

Traditional Chinese medicine (TCM) is applied in various forms, such as decoction pieces, raw powder, extract, and patent Chinese medicine, etc. Controlling exogenous microbial contamination, ensuring the safety and effectiveness of traditional Chinese medicine, and selecting the appropriate sterilization technology are the key factors regarding its use. In this study, the literature on sterilization of TCM published from 2001 to 2021 was retrieved from CNKI, Wanfang, VIP, and Web of Science. Subsequently, visualization analysis software named VOSviewer and CiteSpace were used to analyze the application status and trend in TCM sterilization methods in the past 20 years. After screening was performed, 322 studies were included. The journal that published the highest number of studies on TCM sterilization was Electromechanical Information. The author's cooperative network analysis found that the Chinese medicine sterilization field mainly formed the China Institute for Food and Drug Control and Guangzhou Institute for Drug Control and other core research teams. Keywords in the literature show that the research on TCM sterilization of traditional Chinese medicine mainly focuses on irradiation, microwave, preparation process, active ingredients, drying, fingerprint, etc. The advantages and disadvantages of different sterilization technologies and their suitable scopes, combined with the future development trend in TCM sterilization, were comprehensively discussed for in-depth analysis, to provide a reference for researchers in selecting appropriate sterilization methods. To further promote the scientific development of TCM sterilization, the authors propose that TCM sterilization should be closely combined with technology, equipment, and policy in the future to facilitate rapid modernization of TCM.

Mucormycosis infected by Actinomucor elegans is relatively serious in the population, so it is urgent need to inactivate Actinomucorelegans. In order to investigate the sterilization effect and mechanisms of contact glow discharge plasma (CGDP) on Actinomucor elegans, the effects of voltage, time and electrolyte on sterilization efficiency were investigated, and the sterilization conditions were confirmed. The sterilization mechanism of CGDP on Actinomucor elegans was explored by analyzing the changes of colony morphology, spore content leakage and peroxidation damage that induced by CGDP treatment. The results showed that CGDP had remarkable sterilization effects on Actinomucor elegans, under the conditions of 560 V, 15 min and Na2SO4 solution, the sterilization rate (η) was up to 90.71%, the colony diameter, spore germination rate and mycelial biomass accumulation all decreased significantly after CGDP treatment, while leakage of intracellular components and degree of peroxidation damage increased, and spore surface became shrinking and rupturing. It was concluded that the Actinomucor elegans was inactivated due to cell membrane integrity destroying induced by CGDP. The results of this paper could provide a reference for the application and mechanism research of CGDP in the field of fungicidal.

In order to enhance the path planning application of the transfer robot in a nuclear radiation environment, this paper addresses the problem of lack of influence from the surrounding environment on the path by the traditional A* algorithm, and introduces the idea of an artificial potential field in the nuclear radiation environment to improve the evaluation function of this algorithm. This was achieved by obtaining the sum of the radiation source repulsion function, obstacle repulsion function, and target point gravitational force function to calculate the combined force received in the grid, thereby ensuring that the planned path is far from the surrounding environment. For the improved A* algorithm, the MATLAB simulation experiments showed a decrease in the nuclear radiation dose by 52.11%~55.29% compared with the traditional A* algorithm, and a decrease in the number of search nodes by 34.67%~46.19% compared with other improved algorithms. Moreover, the safety distance with the radiation sources and surrounding obstacles was constantly maintained, providing a better implementation effect and allowing the verification of the effectiveness and superiority of the improved A* algorithm.

To study the representative dose coefficients near nuclear facilities in the arid regions of Northwest China, a simplified anatomical model of Sphingonotus insects using computed tomography (CT) scanning is proposed. In addition, a voxel model created by using Photoshop and Python is used to assess the results of the simplified anatomical model. The dose coefficients of internal and external 90Sr and 137Cs irradiation on different organs of Sphingonotus insects in the environmental medium are calculated. To verify the feasibility of the proposed model, the results are compared with the dose coefficients reported in the International Commission on Radiological Protection (ICRP)Publication 108. Based on the simplified model adopted by ICRP to arrive at the results reported in Publication 108, the average value of dose coefficients of each organ of the insect is used to calculate the results presented in this paper. The dose coefficients of internal and external 90Sr irradiation for the simplified anatomical model of Sphingonotus were found to be 6.59×10-4 μGyh-1/Bqkg-1 and 6.74×10-4 μGyh-1/Bqkg-1, respectively. Meanwhile, the dose coefficients of internal and external 137Cs irradiation for the simplified anatomical model were 1.34×10-4 μGyh-1/Bqkg-1 and 4.40×10-3 μGyh-1/Bqkg-1, respectively. The dose coefficients were 7.87×10-4μGyh-1/Bqkg-1 and 6.74×10-4μGyh-1/Bqkg-1, respectively. The dose coefficients were 1.33×10-4μGyh-1/Bqkg-1 and 3.51×10-3μGyh-1/Bqkg-1, respectively. The dose coefficients of internal and external 90Sr radiation for reference insects as reported in the ICRP Publication 108 were 1.00×10-2 μGyh-1/Bqkg-1 and 3.90×10-10 μGyh-1/Bqkg-1, respectively. Moreover, the dose coefficients of internal and external 137Cs radiation in the ICRP Publication 108 were 3.20×10-3 μGyh-1/Bqkg-1 and 2.80×10-3 μGyh-1/Bqkg-1, respectively. The above data indicate that the dose coefficients of internal irradiation reported in the ICRP Publication 108 are larger than those calculated using the proposed dosiological model, whereas those of external irradiation in ICRP Publication 108 are smaller. This trend is probably related to the size of the organism, decay rate, and energy of radionuclides. The adoption of a simplified anatomical model, morphologically similar to the organism, and a voxel model, highly overlapping with the organism, in this study allows a visualization of the real exposure situation for the organism considered with high accuracy, proving the feasibility of the insect dosimetry model established in this study.

The S-band electron linear accelerator developed for nondestructive testing is primarily used to inspect pressure vessels, petrochemical parts, and other industrial components. The X-band electron linear accelerator has been developed in RIAMB, owing to its advantageous flexibility and light weight and can be used for on-site testing. The integral solution of the irradiation electron linear accelerator system provided by RIAMB includes an accelerator, transmission line, production management system, automatic storage and retrieval system, and workshop. The electrocurtain accelerator is currently being developed in RIAMB. At present, it includes two models, with maximum accelerating voltages of 200 kV and 150 kV, respectively. The ion beam surface processing technology includes ion implantation surface modifications, magnetic filtration multi-arc ion coatings, and ion beam assisted deposition coatings. It forms a corrosion-resistant, friction-resistant, anti-icing, and friction-reducing film on the surface of parts such as bearings and pitot tubes, which are primarily used in the aerospace field.