Acta Optica Sinica, Volume. 41, Issue 1, 0111001(2021)

Optical Super-Resolution Imaging Based on Frequency Shift

Xiang Hao1, Qing Yang1, Cuifang Kuang1,2, and Xu Liu1,2、*
Author Affiliations
  • 1State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, China
  • 2Ningbo Research Institute, Zhejiang University, Ningbo, Zhejiang 315100, China
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    Optical microscopy is non-invasive, sample-friendly, and fast, rendering itself the major approach for human beings to explore the microcosmic world. However, the diffraction limit has hindered the resolution of all optical imaging systems to approximately half the wavelength of visible light for over a century, until it was fundamentally broken by the development of super-resolution optical fluorescence microscopy. This technology bridges the gap between the electron microscopes (1 nm) and the ordinary optical microscopes (200 nm to 250 nm), but it is essentially useless for most samples, especially those non-fluorescent-labeled. In recent years, inspired by the synthetic aperture imaging, we have developed the optical super-resolution imaging based on frequency shift, providing a new approach to optical super-resolution imaging. As the technique is not limited by the nonlinear effects of fluorescence, it is applicable for both non-fluorescent-labeled and fluorescent-labeled samples. Besides, due to such advantages as fast imaging, high sample universality, and low phototoxicity, the technique shows good prospects in multiple fields, including materials science, biology, and medicine. In this paper, we deliver a detailed overview on both the principles and methods of optical super-resolution imaging based on frequency shift, as well as our prospects to the future development direction of this technique.

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    Xiang Hao, Qing Yang, Cuifang Kuang, Xu Liu. Optical Super-Resolution Imaging Based on Frequency Shift[J]. Acta Optica Sinica, 2021, 41(1): 0111001

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    Paper Information

    Category: Imaging Systems

    Received: Aug. 24, 2020

    Accepted: Oct. 12, 2020

    Published Online: Feb. 23, 2021

    The Author Email: Liu Xu (liuxu@zju.edu.cn)

    DOI:10.3788/AOS202141.0111001

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