[1] J E LEMONS. Ceramics: past, present, and future. Bone, 121S(1996).

[2] D F WILLIAMS. The plasticity of biocompatibility. Biomaterials, 296: 122077(2023).

[3] D WILLIAMS. Revisiting the definition of biocompatibility. Med. Device Technol., 10(2003).

[4] Y WANG. Bioadaptability: an innovative concept for biomaterials. J. Mater. Sci. Technol., 801(2016).

[5] X XU, Z JIA, Y ZHENG et al. Bioadaptability of biomaterials: aiming at precision medicine. Matter, 2648(2021).

[6] M MASTROGIACOMO, S SCAGLIONE, R MARTINETTI et al. Role of scaffold internal structure on in vivo bone formation in macroporous calcium phosphate bioceramics. Biomaterials, 3230(2006).

[7] W H TUAN, Y C CHEN, P Y HSU et al. Microstructure design for bone void filler. Int. J. Appl. Ceram. Technol., 869(2022).

[8] J DIAO, J OUYANG, T DENG et al. 3D-plotted beta-tricalcium phosphate scaffolds with smaller pore sizes improve in vivo bone regeneration and biomechanical properties in a critical-sized calvarial defect rat model. Adv. Healthc. Mater.(2018).

[9] M LI, X FU, H GAO et al. Regulation of an osteon-like concentric microgrooved surface on osteogenesis and osteoclastogenesis. Biomaterials, 216: 119269(2019).

[10] D XU, Y WAN, Z LI et al. Tailorable hierarchical structures of biomimetic hydroxyapatite micro/nano particles promoting endocytosis and osteogenic differentiation of stem cells. Biomater. Sci., 3286(2020).

[11] Y WEI, H GAO, L HAO et al. Constructing a Sr²⁺-substituted surface hydroxyapatite hexagon-like microarray on 3D-plotted hydroxyapatite scaffold to regulate osteogenic differentiation. Nanomaterials (Basel), 1672(2020).

[12] X LIU, N ZHAO, H LIANG et al. Bone tissue engineering scaffolds with HUVECs/hBMSCs cocultured on 3D-printed composite bioactive ceramic scaffolds promoted osteogenesis/ angiogenesis. J. Orthop. Translat., 37: 152(2022).

[13] Q LU, J DIAO, Y WANG et al. 3D printed pore morphology mediates bone marrow stem cell behaviors via RhoA/ROCK2 signaling pathway for accelerating bone regeneration. Bioact. Mater., 26: 413(2023).

[14] J J DIAO, H W DING, M Q HUANG et al. Bone defect model dependent optimal pore sizes of 3D-plotted beta-tricalcium phosphate scaffolds for bone regeneration. Small Methods, 11(2019).

[15] C SONG, L LIU, Z DENG et al. Research progress on the design and performance of porous titanium alloy bone implants. J. Mater. Res. Technol., 23: 2626(2023).

[16] K LIN, L CHEN, H QU et al. Improvement of mechanical properties of macroporous β-tricalcium phosphate bioceramic scaffolds with uniform and interconnected pore structures. Ceram. Int., 2397(2011).

[17] J LU, Z WANG. Microstructure of bioceramics:biological effects and clinical application, 26(2020).

[18] H MOHAMMADI, M SEPANTAFAR, N MUHAMAD et al. How does scaffold porosity conduct bone tissue regeneration. Adv. Eng. Mater., 2100463(2021).

[19] J X LU, B FLAUTRE, K ANSELME et al. Role of interconnections in porous bioceramics on bone recolonization in vitro and in vivo. J. Mater. Sci. Mater. Med., 111(1999).

[20] J M CHA, Y S HWANG, D K KANG et al. Development of a novel perfusion rotating wall vessel bioreactor with ultrasound stimulation for mass-production of mineralized tissue constructs. Tissue Eng. Regen. Med., 739(2022).

[21] Y XIE, P HARDOUIN, Z ZHU et al. Three-dimensional flow perfusion culture system for stem cell proliferation inside the critical-size beta-tricalcium phosphate scaffold. Tissue Eng., 3535(2006).

[22] Y XIE, Z ZHU, T TANG et al. Using perfusion bioreactor for mesenchymal stem cell proliferation in large tricalcium phosphate scaffold. Chinese J. Orthop., 1633(2006).

[23] D P FORRESTAL, M C ALLENBY, B SIMPSON et al. Personalized volumetric tissue generation by enhancing multiscale mass transport through 3D printed scaffolds in perfused bioreactors. Adv. Healthc. Mater.(2022).

[24] N ENGEL, C FECHNER, A VOGES et al. An optimized 3D-printed perfusion bioreactor for homogeneous cell seeding in bone substitute scaffolds for future chairside applications. Sci. Rep., 22228(2021).

[25] M DING, K E KOROMA, D WENDT et al. Efficacy of bioreactor-activated bone substitute with bone marrow nuclear cells on fusion rate and fusion mass microarchitecture in sheep. J. Biomed. Mater. Res. B Appl. Biomater., 1862(2022).

[26] P KAZIMIERCZAK, A PRZEKORA. Bioengineered living bone grafts: a concise review on bioreactors and production techniques in vitro. Int. J. Mol. Sci., 1765(2022).

[27] Z ZHANG, J DU, Z WEI et al. Numerical simulation of dynamic seeding of mesenchymal stem cells in pore structure. Comput. & Mathemat. Appl., 88(2020).

[28] Y KUBOKI, Q M JIN, H TAKITA. Geometry of carriers controlling phenotypic expression in BMP-induced osteogenesis and chondrogenesis. Bone and Joint Surg.-Am., 83A: S105(2001).

[29] C MAHAPATRA, P KUMAR, M K PAUL et al. Angiogenic stimulation strategies in bone tissue regeneration. Tissue Cell, 79: 101908(2022).

[30] J GUERRERO, E MAEVSKAIA, C GHAYOR et al. Influence of scaffold microarchitecture on angiogenesis and regulation of cell differentiation during the early phase of bone healing: a transcriptomics and histological analysis. Int. J. Mol. Sci., 6000(2023).

[31] F BAI, Z WANG, J LU et al. The correlation between the internal structure and vascularization of controllable porous bioceramic materials in vivo: a quantitative study. Tissue Eng. Part A, 3791(2010).

[32] S W CHOI, Y ZHANG, M R MACEWAN et al. Neovascularization in biodegradable inverse opal scaffolds with uniform and precisely controlled pore sizes. Adv. Healthc. Mater., 145(2013).

[33] M SHEN, Y LI, F LU et al. Bioceramic scaffolds with triply periodic minimal surface architectures guide early-stage bone regeneration. Bioact. Mater., 25: 374(2023).

[34] G LUTZWEILER, HALILI A NDREU, VRANA N ENGIN. The overview of porous, bioactive scaffolds as instructive biomaterials for tissue regeneration and their clinical translation. Pharmaceutics, 602(2020).

[35] X XIAO, W WANG, D LIU et al. The promotion of angiogenesis induced by three-dimensional porous beta-tricalcium phosphate scaffold with different interconnection sizes via activation of PI3K/Akt pathways. Sci. Rep., 5: 9409(2015).

[36] S NAMKOONG, S J LEE, C K KIM et al. Prostaglandin E2 stimulates angiogenesis by activating the nitric oxide/cGMP pathway in human umbilical vein endothelial cells. Exp. Mol. Med., 588(2005).

[37] J DULAK, A JOZKOWICZ. Nitric oxide and angiogenic activity of endothelial cells: direct or VEGF-dependent effect. Cardiovasc. Res., 489(2002).

[38] J LI, H HUANG, T XU et al. Effect of the interconnecting window diameter of hydroxyapatite scaffolds on vascularization and osteoinduction. Ceram. Int., 25070(2022).

[39] Y J LU, Z WANG, X LU et al. Minimally invasive treatment for osteonecrosis of the femoral head in ARCO stage Ⅱ and Ⅲ with bioceramic system. Chin. J. Repar. Reconst. Surgery, 1291(2019).

[40] A MURAYAMA, T AJIKI, Y HAYASHI et al. A unidirectional porous beta-tricalcium phosphate promotes angiogenesis in a vascularized pedicle rat model. J. Orthop. Sci., 1118(2019).

[41] T KUNISADA, J HASEI, T FUJIWARA et al. Radiographic and clinical assessment of unidirectional porous hydroxyapatite to treat benign bone tumors. Sci. Rep., 10: 21578(2020).

[42] H KUMAGAI, T MAKIHARA, T FUNAYAMA et al. Angiogenesis and new bone formation in novel unidirectional porous beta-tricalcium phosphate: a histological study. J. Artif. Organs., 294(2019).

[43] K IKUTA, Y NISHIDA, T OTA et al. A clinical trial of a unidirectional porous tricalcium phosphate filling for defects after resection of benign bone lesions: a prospective multicenter study. Sci. Rep., 12: 16060(2022).

[44] Y LU, X LU, M LI et al. Minimally invasive treatment for osteonecrosis of the femoral head with angioconductive bioceramic rod.. Int. Orthop., 1567(2018).

[45] J LU, M DESCAMPS, J DEJOU et al. The biodegradation mechanism of calcium phosphate biomaterials in bone. J. Biomed. Mater. Res., 408(2002).

[46] Y ZHANG, T SHU, S WANG et al. The osteoinductivity of calcium phosphate-based biomaterials: a tight interaction with bone healing. Front Bioeng. Biotechnol., 10: 911180(2022).

[47] P STASTNY, R SEDLACEK, T SUCHY et al. Structure degradation and strength changes of sintered calcium phosphate bone scaffolds with different phase structures during simulated biodegradation in vitro. Mater. Sci. Eng.: C, 100: 544(2019).

[48] Y C CHAI, A CARLIER, J BOLANDER et al. Current views on calcium phosphate osteogenicity and the translation into effective bone regeneration strategies. Acta Biomater., 3876(2012).

[49] C P G SANTOS, J P S PRADO, K R FERNANDES et al. Different species of marine sponges diverge in osteogenic potential when therapeutically applied as natural scaffolds for bone regeneration in rats. J. Funct. Biomater., 112(2023).

[50] I AVERIANOV, M STEPANOVA, O SOLOMAKHA et al. 3D-printed composite scaffolds based on poly(ε-caprolactone) filled with poly(glutamic acid)‐modified cellulose nanocrystals for improved bone tissue regeneration. J. Biomed. Mater. Res. B: Appl. Biomater., 2422(2022).

[51] X CHENG, X YANG, C LIU et al. Stabilization of apatite coatings on PPENK surfaces by mechanical interlocking to promote bioactivity and osseointegration in vivo. ACS Appl. Mater. Interf., 697(2023).

[52] R KUMAR, I PATTANAYAK, P A DASH et al. Bioceramics: a review on design concepts toward tailor-made (multi)-functional materials for tissue engineering applications. J. Mater. Sci., 3460(2023).

[53] S TAJVAR, A HADJIZADEH, S S SAMANDARI. Scaffold degradation in bone tissue engineering: an overview. Int. Biodeter. & Biodegr., 105599(2023).

[54] M BOHNER, B L G SANTONI, N DOBELIN. Beta-tricalcium phosphate for bone substitution: synthesis and properties. Acta Biomater., 113: 23(2020).

[55] J X LU, M C BLARY, S VAVASSEUR et al. Relationship between bioceramics sintering and micro-particles-induced cellular damages. J. Mater. Sci. Mater. Med., 361(2004).

[56] Z SHEIKH, M N ABDALLAH, A A HANAFI et al. Mechanisms of in vivo degradation and resorption of calcium phosphate based biomaterials. Materials (Basel), 7913(2015).

[57] J L SIMON, T D ROY, J R PARSONS et al. Engineered cellular response to scaffold architecture in a rabbit trephine defect. J. Biomed. Mater. Res. A, 275(2003).

[58] J X LU, A GALLUR, B FLAUTRE et al. Comparative study of tissue reactions to calcium phosphate ceramics among cancellous, cortical, and medullar bone sites in rabbits. J. Biomed. Mater. Res., 357(1998).

[59] L GALOIS, D MAINARD, J P DELAGOUTTE. Beta-tricalcium phosphate ceramic as a bone substitute in orthopaedic surgery. Int. Orthop., 109(2002).

[60] Z WANG, B LU, L CHEN et al. Evaluation of an osteostimulative putty in the sheep spine. J. Mater. Sci. Mater. Med., 185(2011).

[61] W ZHI, X WANG, D SUN et al. Optimal regenerative repair of large segmental bone defect in a goat model with osteoinductive calcium phosphate bioceramic implants. Bioact. Mater., 11: 240(2022).

[62] C HAMPP, N ANGRISANI, J REIFENRATH et al. Evaluation of the biocompatibility of two magnesium alloys as degradable implant materials in comparison to titanium as non-resorbable material in the rabbit. Mater. Sci. Eng. C Mater. Biol. Appl., 317(2013).

[63] Z WANG, Z GUO, H BAI et al. Clinical evaluation of beta-TCP in the treatment of lacunar bone defects: a prospective, randomized controlled study. Mater. Sci. Eng. C Mater. Biol. Appl., 1894(2013).

[64] E DEHOUX, K MADI, E FOURATI et al. High tibial open-wedge osteotomy using a tricalcium phosphate substitute: 70 cases with 18 months mean follow-up. Rev. Chir. Orthop. Reparatrice. Appar. Mot., 143(2005).

[65] P HERNIGOU, X ROUSSIGNOL, C H FLOUZAT-LACHANIETTE et al. Opening wedge tibial osteotomy for large varus deformity with ceraver resorbable beta-tricalcium phosphate wedges. Int. Orthop., 191(2010).

[66] T KRAAL, M MULLENDER, BRUINE J H DE et al. Resorbability of rigid beta-tricalcium phosphate wedges in open-wedge high tibial osteotomy: a retrospective radiological study. Knee, 201(2008).

[67] T TANAKA, Y KUMAGAE, M SAITO et al. Bone formation and resorption in patients after implantation of beta-tricalcium phosphate blocks with 60% and 75% porosity in opening-wedge high tibial osteotomy. J. Biomed. Mater. Res. B Appl. Biomater., 453(2008).

[68] A OGOSE, T HOTTA, H KAWASHIMA et al. Comparison of hydroxyapatite and beta tricalcium phosphate as bone substitutes after excision of bone tumors. J. Biomed. Mater. Res. B Appl. Biomater., 94(2005).

[69] M HIRATA, H MURATA, H TAKESHITA et al. Use of purified beta-tricalcium phosphate for filling defects after curettage of benign bone tumours. Int. Orthop., 510(2006).

[70] B JAVAHERI, A A PITSILLIDES. Aging and mechanoadaptive responsiveness of bone. Curr. Osteoporos. Rep., 560(2019).

[71] Y ZHANG, Q ZHANG, F HE et al. Fabrication of cancellous- bone-mimicking β-tricalcium phosphate bioceramic scaffolds with tunable architecture and mechanical strength by stereolithography 3D printing. J. Europ. Ceram. Soci., 6713(2022).

[72] F ZHANG, J CHANG, J LU et al. Bioinspired structure of bioceramics for bone regeneration in load-bearing sites. Acta Biomater., 896(2007).

[73] KAILI LIN, XIAOHONG WANG, G S STEVE et al. Research progress on functional modifications and applications of bioceramic scaffolds. J. Inorg. Mater., 867(2020).

[74] X MIAO, D SUN. Graded/gradient porous biomaterials. Materials, 26(2009).

[75] E R HENDERSON, J S GROUNDLAND, E PALA et al. Failure mode classification for tumor endoprostheses: retrospective review of five institutions and a literature review. J. Bone Joint. Surg. Am., 418(2011).

[76] J K KENDAL, C D HAMAD, A G ABBOTT et al. What are the indications and survivorship of tumor endoprosthetic reconstructions for patients with extremity metastatic bone disease. J. Surg. Oncol., 1196(2023).

[77] Y LU, G CHEN, Z LONG et al. Novel 3D-printed prosthetic composite for reconstruction of massive bone defects in lower extremities after malignant tumor resection. J. Bone Oncol., 16: 100220(2019).

[78] C N KELLY, T WANG, J CROWLEY et al. High-strength, porous additively manufactured implants with optimized mechanical osseointegration. Biomaterials, 279: 121206(2021).

[79] L HAIJIE, L DASEN, J TAO et al. Implant survival and complication profiles of endoprostheses for treating tumor around the knee in adults: a systematic review of the literature over the past 30 years. J. Arthroplasty, 1275(2018).

[80] S VIJAYAVENKATARAMAN, A GOPINATH, W F LU. A new design of 3D-printed orthopedic bone plates with auxetic structures to mitigate stress shielding and improve intra-operative bending. Bio-Design Manufact., 98(2020).

[81] A M POBLOTH, S CHECA, H RAZI et al. Mechanobiologically optimized 3D titanium-mesh scaffolds enhance bone regeneration in critical segmental defects in sheep. Sci. Transl. Med., 8828(2018).

[82] N WU, S LI, B ZHANG et al. The advances of topology optimization techniques in orthopedic implants: a review. Med. Biol. Eng. Comput., 1673(2021).

[83] S SAFAVI, Y YU, D L ROBINSON et al. Additively manufactured controlled porous orthopedic joint replacement designs to reduce bone stress shielding: a systematic review. J. Orthop. Surg. Res., 42(2023).

[84] J YUAN, B WANG, C HAN et al. Nanosized-Ag-doped porous beta-tricalcium phosphate for biological applications. Mater. Sci. Eng. C Mater. Biol. Appl., 114: 111037(2020).

[85] J YUAN, B WANG, C HAN, et al.. J. Mater. Sci. Mater. Med., 174(2015).

[86] X M GUO, C Y WANG, C M DUAN et al. Repair of osteochondral defects with autologous chondrocytes seeded onto bioceramic scaffold in sheep. Tissue Eng., 1830(2004).

[87] X M GUO, C Y WANG, Y F ZHANG et al. Repair of large articular cartilage defects with implants of autologous mesenchymal stem cells seeded into beta-tricalcium phosphate in a sheep model. Tissue Eng., 10, 1818(2004).

[88] D LI, M LI, P LIU et al. Tissue-engineered bone constructed in a bioreactor for repairing critical-sized bone defects in sheep. Int. Orthop., 2399(2014).

[89] P SPONER, T KUCERA, J BRTKOVA et al. Comparative study on the application of mesenchymal stromal cells combined with tricalcium phosphate scaffold into femoral bone defects. Cell Transplant., 1459(2018).

[90] V FATALE, S PAGNONI, A E PAGNONI et al. Histomorphometric comparison of new bone formed after maxillary sinus lift with lateral and crestal approaches using periostal mesenchymal stem cells and beta-tricalcium phosphate: a controlled clinical trial. J. Craniofac. Surg., 1607(2022).

[91] W CHU, X WANG, Y GAN et al. Screen-enrich-combine circulating system to prepare MSC/beta-TCP for bone repair in fractures with depressed tibial plateau. Regen. Med., 555(2019).

[92] J F BLANCO, E M VILLARON, D PESCADOR et al. Autologous mesenchymal stromal cells embedded in tricalcium phosphate for posterolateral spinal fusion: results of a prospective phase I/II clinical trial with long-term follow-up. Stem Cell Res. Ther., 63(2019).

[93] J LYU, T MA, X HUANG et al. Core decompression with β-tri-calcium phosphate grafts in combination with platelet-rich plasma for the treatment of avascular necrosis of femoral head. BMC Musculoskelet. Disord., 40(2023).

[94] Y GAO, J CHENG, Z LONG et al. Repair of segmental ulnar bone defect in juvenile caused by osteomyelitis with induced membrane combined with tissue-engineered bone:a case report with 4-year follow-up. Int. J. Surg. Case Rep.(2022).

[95] S GUPTA, A MALHOTRA, R JINDAL et al. Role of beta tri-calcium phosphate-based composite ceramic as bone-graft expander in masquelet’s-induced membrane technique. Indian J. Orthop., 63(2019).

[96] G SASAKI, Y WATANABE, W MIYAMOTO et al. Induced membrane technique using beta-tricalcium phosphate for reconstruction of femoral and tibial segmental bone loss due to infection: technical tips and preliminary clinical results. Int. Orthop., 17(2018).

[97] T F RAVEN, A MOGHADDAM, C ERMISCH et al. Use of Masquelet technique in treatment of septic and atrophic fracture nonunion. Injury, 40(2019).

[98] F JUN, G ZHENG, F HONGBIN et al. Aplication of 3D-printed prosthesis on construction of long segmental bone defect after tumor resection. Chin. J. Orthop., 433(2017).

[99] X HU, S KENAN, M CHENG et al. 3D-printed patient-customized artificial vertebral body for spinal reconstruction after total En Bloc spondylectomy of complex multi-level spinal tumors. Int. J. Bioprint., 576(2022).

[100] T S BROWN, C G SALIB, P S ROSE et al. Reconstruction of the hip after resection of periacetabular oncological lesions: a systematic review. Bone Joint J., 2018.

[101] D THOMAS, D SINGH. 3D-printing for engineering the next generation of artificial trabecular bone structures. Int. J. Surg., 46: 195(2017).

[102] P GAO, H ZHANG, Y LIU et al. Beta-tricalcium phosphate granules improve osteogenesis in vitro and establish innovative osteo-regenerators for bone tissue engineering in vivo. Sci. Rep., 6: 23367(2016).