Fig. 1. (Color online) A wearable electrochemical biosensor patch for wireless monitoring CRP from sweat^[14]. (a) Circulating CRP obtained from the sweat gland could reflect inflammatory responses to chronic and acute health conditions. (b) Schematic illustration of the skin-interfaced wearable biosensor with multiple modules, including iontophoresis, microfluidics, LEG-based multimodal sensor arrays, and FPCB. (c) Optical image of the disposable microfluidic component. (d) Optical image of the vertically stacked sweat sensor patch. (Scale bars: 0.5 cm). (e) The working principle of the sensor patch for in-situ sweat CRP analysis. (f) Schematic illustrating non-invasive inflammation monitoring in various health conditions using the sensor patch. (g) Box-and-whisker plot of CRP analysis for iontophoresis-extracted sweat and serum samples from COPD and non-COPD patients.