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Journal of Radiation Research and Radiation Processing, Volume. 42, Issue 5, 050301(2024)

Non-invasive evaluation of epidermal growth factor receptor expression in gastric cancer animal models using 124I-labeled antibody and antibody fragment

Liming CHAI... Xiaolong YAO, Renhua NA, Wei YAN, Mingzheng JIANG, Canwen SUN, Zeqiang DAI, Haixu ZHU and Xiaofeng YANG* |Show fewer author(s)
Author Affiliations
  • Department of Nuclear Medicine, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China
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    The overall experimental process

    Fig. 1. The overall experimental process

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    Quality control results for Cetuximab, Cet-F(ab')2 and Cet-Fab (M: protein marker; T: target protein)

    Fig. 2. Quality control results for Cetuximab, Cet-F(ab')2 and Cet-Fab (M: protein marker; T: target protein)

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    Immunofluorescence results of MGC803 cell line (×100) (BF: light field)

    Fig. 3. Immunofluorescence results of MGC803 cell line (×100) (BF: light field)

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    Quality control and binding assays of 124I-Cetuximab, 124I-Cet-F(ab')2 and 124I-Cet-Fab: (a) iTLC results for 124I-Cetuximab; (b) iTLC results for 124I-Cet-F(ab')2; (c) iTLC results for 124I-Cet-Fab; (d) results of saturation experiments with 124I-Cetuximab; (e) results of saturation experiments for 124I-Cet-F(ab')2; (f) results of saturation experiments with 124I-Cet-Fab

    Fig. 4. Quality control and binding assays of 124I-Cetuximab, 124I-Cet-F(ab')2 and 124I-Cet-Fab: (a) iTLC results for 124I-Cetuximab; (b) iTLC results for 124I-Cet-F(ab')2; (c) iTLC results for 124I-Cet-Fab; (d) results of saturation experiments with 124I-Cetuximab; (e) results of saturation experiments for 124I-Cet-F(ab')2; (f) results of saturation experiments with 124I-Cet-Fab

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    Micro-PET/CT imaging: (a) 124I-Cetuximab; (b) 124I-Cet-Fab; (c) 124I-Cet-F(ab')2; and biological distribution results:(d) 124I-Cetuximab; (e) 124I-Cet-Fab; (f) 124I-Cet-F(ab')2 (The dotted white line indicates the tumor) (color online)

    Fig. 5. Micro-PET/CT imaging: (a) 124I-Cetuximab; (b) 124I-Cet-Fab; (c) 124I-Cet-F(ab')2; and biological distribution results:(d) 124I-Cetuximab; (e) 124I-Cet-Fab; (f) 124I-Cet-F(ab')2 (The dotted white line indicates the tumor) (color online)

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    Immunohistochemistry and H&E staining of MGC803 tumor tissue

    Fig. 6. Immunohistochemistry and H&E staining of MGC803 tumor tissue

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    Liming CHAI, Xiaolong YAO, Renhua NA, Wei YAN, Mingzheng JIANG, Canwen SUN, Zeqiang DAI, Haixu ZHU, Xiaofeng YANG. Non-invasive evaluation of epidermal growth factor receptor expression in gastric cancer animal models using 124I-labeled antibody and antibody fragment[J]. Journal of Radiation Research and Radiation Processing, 2024, 42(5): 050301

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    Paper Information

    Category: RADIOBIOLOGY AND RADIOMEDICINE

    Received: Jan. 26, 2024

    Accepted: Mar. 17, 2024

    Published Online: Jan. 2, 2025

    The Author Email: YANG Xiaofeng (杨小丰)

    DOI:10.11889/j.1000-3436.2024-0002

    Topics

    laser devices and laser physics
    Lasers and Laser Optics
    Laser physics
    laser manufacturing
    Instrumentation, Measurement and Metrology