Fig. 1. Effects of CpG-ODN on spleen index after CIR. the change of spleen index after CIR at the 1st and 3rd day; *p<0.05, compared with CIR control group

Fig. 2. Effects of CpG-ODN on spleen damage after CIR: (a) representative of histological specimens of spleen after CIR at 1st and 3rd day; (b) proportion of white pulp in spleen was quantified; *p<0.05, compared with CIR control group

Fig. 3. Effects of CpG-ODN on DNA DSB and apoptosis of spleen cell after CIR: (a) expression of γ-H₂AX protein in spleen was detected by immunohistochemistry after CIR; (b) the number of apoptotic cells in spleen was detected by TUNEL assay after CIR

Fig. 4. Effects of CpG-ODN on CD19⁺B cells in peripheral blood: (a) the number of CD19⁺B cells in peripheral blood after CIR at 1st and 3rd day detected by CD19⁺labeling; (b) the number of CD19⁺cell quantified; *p<0.05, compared with CIR control group