Journal of Radiation Research and Radiation Processing, Volume. 41, Issue 4, 040301(2023)

Effect of CpG-ODN on spleen damage after carbon ion radiation

Chao ZHANG1... Hua FU1,*, Yonghua YI1, Jianming CAI2 and Fu GAO2 |Show fewer author(s)
Author Affiliations
  • 1Department of Radiotherapy, The 940 Hospital of Joint Logistic Support Force of PLA., Lanzhou 730050, China
  • 2Faculty of Naval Medicine, Naval Military Medical University, Shanghai 200433, China
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    Figures & Tables(4)
    Effects of CpG-ODN on spleen index after CIR. the change of spleen index after CIR at the 1st and 3rd day; *p<0.05, compared with CIR control group
    Effects of CpG-ODN on spleen damage after CIR: (a) representative of histological specimens of spleen after CIR at 1st and 3rd day; (b) proportion of white pulp in spleen was quantified; *p<0.05, compared with CIR control group
    Effects of CpG-ODN on DNA DSB and apoptosis of spleen cell after CIR: (a) expression of γ-H2AX protein in spleen was detected by immunohistochemistry after CIR; (b) the number of apoptotic cells in spleen was detected by TUNEL assay after CIR
    Effects of CpG-ODN on CD19+B cells in peripheral blood: (a) the number of CD19+B cells in peripheral blood after CIR at 1st and 3rd day detected by CD19+labeling; (b) the number of CD19+cell quantified; *p<0.05, compared with CIR control group
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    Chao ZHANG, Hua FU, Yonghua YI, Jianming CAI, Fu GAO. Effect of CpG-ODN on spleen damage after carbon ion radiation[J]. Journal of Radiation Research and Radiation Processing, 2023, 41(4): 040301

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    Paper Information

    Category: Research Articles

    Received: Nov. 10, 2022

    Accepted: Feb. 12, 2023

    Published Online: Sep. 21, 2023

    The Author Email:

    DOI:10.11889/j.1000-3436.2022-0116

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