Based on the theory of angular spectrum representation, the non-Gaussian rough surface is simulated by Johnson transfer system, and the field distribution characteristics of Laguerre-Gaussian vortex beams passing through the random non-Gaussian rough surface are studied. The effects of the direction correlation length, kurtosis, skewness and root mean square roughness of non-Gaussian rough surface on the field distribution of the vortex beam are analyzed. The range of the root mean square roughness is studied when the intensity distribution of the vortex beam passing through the random rough surface changes, and the corresponding experiment is carried out. The experimental data are compared with the simulation results. The results show that when the direction correlation length of non-Gaussian rough surface is 20 mm, the skewness is 0.001, the kurtosis is 6, and the root mean square roughness is more than 0.12 mm, the intensity distribution of the Laguerre-Gaussian beam passing through the random surface no longer keeps the hollow distribution, and the corresponding phase singularity disappears.