Journals Articles Conferences News About CLP
Submit a paper Email Alert
Search
Search
Articles
Journals
News
Advanced Search
Top Searches
2D MaterialsTransformation opticsQuantum PhotonicsSmall lasersSemiconductor UV PhotonicsSupersymmetric microring laser arrays

Photonics Research, Volume. 11, Issue 5, 732(2023)

Biosensing with free space whispering gallery mode microlasers

Angela Capocefalo1、†, Silvia Gentilini1、†, Lorenzo Barolo2, Paola Baiocco2, Claudio Conti1,3, and Neda Ghofraniha1、*
Author Affiliations
  • 1Istituto dei Sistemi Complessi-CNR, UOS Università La Sapienza, I-00185 Rome, Italy
  • 2Dipartimento di Scienze Biochimiche A. Rossi Fanelli, Università La Sapienza, I-00185 Rome, Italy
  • 3Dipartimento di Fisica, Università La Sapienza, I-00185 Rome, Italy
    • show less
    Full TextGet PDF
    Figures&Tables (8)
    Equations (1)
    References (50)
    Cited By (3)
    Tools
    Paper Information
    Topics
    References(50)

    [1] L. Cai, J. Pan, Y. Zhao, J. Wang, S. Xiao. Whispering gallery mode optical microresonators: structures and sensing applications. Phys. Status Solidi A, 217, 1900825(2020).

    [2] E. Kim, M. D. Baaske, F. Vollmer. Towards next-generation label-free biosensors: recent advances in whispering gallery mode sensors. Lab Chip, 17, 1190-1205(2017).

    [3] T. Lu, H. Lee, T. Chen, S. Herchak, J.-H. Kim, S. E. Fraser, R. C. Flagan, K. Vahala. High sensitivity nanoparticle detection using optical microcavities. Proc. Natl. Acad. Sci. USA, 108, 5976-5979(2011).

    [4] A. M. Armani, R. P. Kulkarni, S. E. Fraser, R. C. Flagan, K. J. Vahala. Label-free, single-molecule detection with optical microcavities. Science, 317, 783-787(2007).

    [5] C. G. B. Garrett, W. Kaiser, W. L. Bond. Stimulated emission into optical whispering modes of spheres. Phys. Rev., 124, 1807-1809(1961).

    [6] R. E. Benner, P. W. Barber, J. F. Owen, R. K. Chang. Observation of structure resonances in the fluorescence spectra from microspheres. Phys. Rev. Lett., 44, 475-478(1980).

    [7] S. Nizamoglu, M. C. Gather, S. H. Yun. All-biomaterial laser using vitamin and biopolymers. Adv. Mater., 25, 5943-5947(2013).

    [8] T. Reynolds, N. Riesen, A. Meldrum, X. Fan, J. M. M. Hall, T. M. Monro, A. Francoi. Fluorescent and lasing whispering gallery mode microresonators for sensing applications. Laser Photon. Rev., 11, 1600265(2020).

    [9] G. Li, T. Che, X. Ji, S. Liu, Y. Hao, Y. Cui, S. Liu. Record-low-threshold lasers based on atomically smooth triangular nanoplatelet perovskite. Adv. Funct. Mater., 29, 1805553(2019).

    [10] D. Wang, H. W. Seo, C.-C. Tin, M. J. Bozack, J. R. Williams, M. Park, Y. Tzeng. Lasing in whispering gallery mode in ZnO nanonails. J. Appl. Phys., 99, 093112(2006).

    [11] T. Wienhold, S. Kraemmer, S. F. Wondimu, T. Siegle, U. Bog, U. Weinzierl, S. Schmidt, H. Becker, H. Kalt, T. Mappes, S. Koeber, C. Koos. All-polymer photonic sensing platform based on whispering-gallery mode microgoblet lasers. Lab Chip, 15, 3800-3806(2015).

    [12] M. Schubert, A. Steude, P. Liehm, N. M. Kronenberg, M. Karl, E. C. Campbell, S. J. Powis, M. C. Gather. Lasing within live cells containing intracellular optical microresonators for barcode-type cell tagging and tracking. Nano Lett., 15, 5647-5652(2015).

    [13] V. D. Ta, S. Caixeiro, F. M. Fernandes, R. Sapienza. Microsphere solid-state biolasers. Adv. Opt. Mater., 5, 1601022(2017).

    [14] M. Schubert, L. Woolfson, I. R. Barnard, A. M. Dorward, B. Casement, A. Morton, G. B. Robertson, P. L. Appleton, G. B. Miles, C. S. Tucker, S. J. Pitt, M. C. Gather. Monitoring contractility in cardiac tissue with cellular resolution using biointegrated microlasers. Nat. Photonics, 14, 452-458(2020).

    [15] Z. Wang, Y. Zhang, X. Gong, Z. Yuan, S. Feng, T. Xu, T. Liu, Y.-C. Chen. Bio-electrostatic sensitive droplet lasers for molecular detection. Nanoscale Adv., 2, 2713-2719(2020).

    [16] H. Lina, O. S. Kaya, Z. Jiangang, K. Woosung, Y. Lan. Detecting single viruses and nanoparticles using whispering gallery microlasers. Nat. Nanotechnol., 6, 428-432(2011).

    [17] M. Humar, S. H. Yun. Intracellular microlasers. Nat. Photonics, 9, 572-576(2015).

    [18] N. Toropov, G. Cabello, M. P. Serrano, R. R. Gutha, M. Rafti, F. Vollmer. Review of biosensing with whispering-gallery mode lasers. Light Sci. Appl., 10, 1(2021).

    [19] D. D’Ambrosio, M. Capezzuto, S. Avino, P. Malara, A. Giorgini, P. D. Natale, G. Gagliardi. Light pressure in droplet micro-resonators excited by free-space scattering. Opt. Lett., 46, 3111-3114(2021).

    [20] D. D’Ambrosio, X. Zambrana-Puyalto, M. Capezzuto, A. Giorgini, P. Malara, S. Avino, G. Gagliardi. Angular-momentum coupling of optical whispering-gallery modes to liquid droplet microresonators. Phys. Rev. A, 104, 043504(2021).

    [21] M. Himmelhaus, A. Francois. In-vitro sensing of biomechanical forces in live cells by a whispering gallery mode biosensor. Biosens. Bioelectron., 25, 418-427(2009).

    [22] W. Chen, J. Zhang, B. Peng, Ş. K. Özdemir, X. Fan, L. Yang. Parity-time-symmetric whispering-gallery mode nanoparticle sensor. Photon. Res., 6, A23-A30(2018).

    [23] D. S. Weiss, V. Sandoghdar, J. Hare, V. Lefèvre-Seguin, J.-M. Raimond, S. Haroche. Splitting of high-Q Mie modes induced by light backscattering in silica microspheres. Opt. Lett., 20, 1835-1837(1995).

    [24] Z. Yuan, Z. Wang, P. Guan, X. Wu, Y.-C. Chen. Lasing-encoded microsensor driven by interfacial cavity resonance energy transfer. Adv. Opt. Mater., 8, 1901596(2020).

    [25] A. Jonas, M. Aas, Y. Karadag, S. Manioglu, S. Anand, D. McGloin, H. Bayraktar, A. Kiraz. In vitro and in vivo biolasing of fluorescent proteins suspended in liquid microdroplet cavities. Lab Chip, 14, 3093-3100(2014).

    [26] W. Lee, Q. Chen, X. Fan, D. K. Yoon. Digital DNA detection based on a compact optofluidic laser with ultra-low sample consumption. Lab Chip, 16, 4770-4776(2016).

    [27] C. Gong, Y. Gong, X. Zhao, Y. Luo, Q. Chen, X. Tan, Y. Wu, X. Fan, G.-D. Peng, Y.-J. Rao. Distributed fibre optofluidic laser for chip-scale arrayed biochemical sensing. Lab Chip, 18, 2741-2748(2018).

    [28] O. Erol, T. Pelin, A. Ozan, H. Ersin, B. Mehmet. Label-free biosensing with high selectivity in complex media using microtoroidal optical resonators. Sci. Rep., 5, 13173(2015).

    [29] S. Soria, F. Baldini, S. Berneschi, F. Cosi, A. Giannetti, G. N. Conti, S. Pelli, G. Righini, B. Tiribilli. High-Q polymer-coated microspheres for immunosensing applications. Opt. Express, 17, 14694-14699(2009).

    [30] E. Kim, M. D. Baaske, F. Vollmer. In situ observation of single-molecule surface reactions from low to high affinities. Adv. Mater., 28, 9941-9948(2016).

    [31] Y. Chen, U. Schoeler, C. Huang, F. Vollmer. Combining whispering-gallery mode optical biosensors with microfluidics for real-time detection of protein secretion from living cells in complex media. Small, 14, 1703705(2018).

    [32] H. H. Mai, T. T. Nguyen, K. M. Giang, X. T. Do, T. T. Nguyen, H. C. Hoang, V. D. Ta. Chicken albumen-based whispering gallery mode microlasers. Soft Matter, 16, 9069-9073(2020).

    [33] A. Francois, N. Riesen, H. Ji, S. Afshar V., T. M. Monro. Polymer based whispering gallery mode laser for biosensing applications. Appl. Phys. Lett., 106, 031104(2015).

    [34] A. Capocefalo, E. Quintiero, M. Bianco, A. Zizzari, S. Gentilini, C. Conti, V. Arima, I. Viola, N. Ghofraniha. Random laser spectral fingerprinting of lithographed microstructures. Adv. Mater. Technol., 6, 2001037(2021).

    [35] A. Capocefalo, E. Quintiero, C. Conti, N. Ghofraniha, I. Viola. Droplet lasers for smart photonic labels. ACS Appl. Mater. Interfaces, 13, 51485-51494(2021).

    [36] N. Ghofraniha, L. La Volpe, D. Van Opdenbosch, C. Zollfrank, C. Conti. Biomimetic random lasers with tunable spatial and temporal coherence. Adv. Opt. Mater., 4, 1998-2003(2016).

    [37] G. Righini, Y. Dumeige, P. Feron, M. Ferrari, G. N. Conti, D. Ristic, S. Soria. Whispering gallery mode microresonators: Fundamentals and applications. Riv. Nuovo Cim., 34, 435-488(2011).

    [38] A. Soloperto, D. Quaglio, P. Baiocco, I. Romeo, M. Mori, M. Ardini, C. Presutti, I. Sannino, S. Ghirga, A. Iazzetti, R. Ippoliti, G. Ruocco, B. Botta, F. Ghirga, S. Di Angelantonio, A. Boffi. Rational design and synthesis of a novel bodipy-based probe for selective imaging of tau tangles in human IPSC-derived cortical neurons. Sci. Rep., 12, 5257(2022).

    [39] A. Tavlove, S. Hagness. Computational Electrodynamics: The Finite-Difference Time-Domain Method(2000).

    [40] S. Gentilini, A. Fratalocchi, L. Angelani, G. Ruocco, C. Conti. Ultrashort pulse propagation and the Anderson localization. Opt. Lett., 34, 130-132(2009).

    [41] S. Gentilini, C. Conti. Optomechanics of random media. Phys. Rev. A, 91, 043813(2015).

    [42] D. W. Walker, J. J. Dongarra. MPI: a standard message passing interface. Supercomputer, 12, 56(1996).

    [43] Y. W. Jun, S. W. Cho, J. Jung, Y. Huh, Y. Kim, D. Kim, K. H. Ahn. Frontiers in probing Alzheimer’s disease biomarkers with fluorescent small molecules. ACS Cent. Sci., 5, 209-217(2019).

    [44] M. Baaske, M. Foreman, F. Vollmer. Single-molecule nucleic acid interactions monitored on a label-free microcavity biosensor platform. Nat. Nanotechnol., 9, 933-939(2014).

    [45] F. Saglimbeni, S. Bianchi, G. Bolognesi, G. Paradossi, R. Di Leonardo. Optical characterization of an individual polymer-shelled microbubble structure via digital holography. Soft Matter, 8, 8822-8825(2012).

    [46] S. Armstrong, M. Budka, K. Morrison, M. Hasson. Preparation and properties of serum and plasma proteins. XII. The refractive properties of the proteins of human plasma and certain purified fractions. J. Am. Chem. Soc., 69, 1747-1753(1947).

    [47] G. L. Long, J. D. Winefordner. Limit of detection. A closer look at the IUPAC definition. Anal. Chem., 55, 712A-724A(1983).

    [48] S. Subramanian, H. B. Jones, S. Frustaci, S. Winter, M. W. van der Kamp, V. L. Arcus, C. R. Pudney, F. Vollmer. Sensing enzyme activation heat capacity at the single-molecule level using gold-nanorod-based optical whispering gallery modes. ACS Appl. Nano Mater., 4, 4576-4583(2021).

    [49] S. Shopova, R. Rajmangal, S. Holler, S. Arnold. Plasmonic enhancement of a whispering-gallery-mode biosensor for single nanoparticle detection. Appl. Phys. Lett., 98, 243104(2011).

    [50] T. L. McMeekin, M. L. Groves, N. J. Hipp. Refractive Indices of Amino Acids, Proteins, and Related Substances, 54-66(1964).

    Tools

    Get Citation

    Copy Citation Text

    Angela Capocefalo, Silvia Gentilini, Lorenzo Barolo, Paola Baiocco, Claudio Conti, Neda Ghofraniha, "Biosensing with free space whispering gallery mode microlasers," Photonics Res. 11, 732 (2023)

    Download Citation

    EndNote(RIS)BibTexPlain Text
    Set citation alerts for article
    Save article for my favorites
    Paper Information

    Category: Optical Devices

    Received: Oct. 5, 2022

    Accepted: Dec. 8, 2022

    Published Online: Apr. 23, 2023

    The Author Email: Neda Ghofraniha (neda.ghofraniha@cnr.it)

    DOI:10.1364/PRJ.477139

    Topics

    laser devices and laser physics
    Lasers and Laser Optics
    Laser physics
    laser manufacturing
    Instrumentation, Measurement and Metrology