Effect of C-band pulse microwave exposure on blood-brain barrier permeability in rats

Jianrong HE; Xianghui WANG; Hongxin QI; Jie ZHANG

doi:10.11889/j.1000-3436.2024-0034

Journal of Radiation Research and Radiation Processing, Volume. 43, Issue 1, 010302(2025)

Effect of C-band pulse microwave exposure on blood-brain barrier permeability in rats

Jianrong HE... Xianghui WANG, Hongxin QI and Jie ZHANG* |Show fewer author(s)

Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, East China Normal University, Shanghai 200241, China

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Figures & Tables(14)

Fig. 1. Schematic diagram of irradiation platform

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Fig. 2. Standard curve chart of EB

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Fig. 3. EB content in rat brain under different field strengths irradiation (n=6, compared with the control group, *p<0.05, **p<0.01）

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Fig. 4. EB fluorescence leakage diagrams in rat brain under different field strengths irradiation（color online）

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Fig. 5. EB content in rat brain under different number of pulses irradiation (n=6, compared to the control group, *p<0.05, **p<0.01）

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Fig. 6. EB fluorescence leakage diagrams in rat brain under different number of pulses irradiation (color online)

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Fig. 7. EB content in rat brain under different pulse widths irradiation (n=6, compared with the control group, **p<0.01）

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Fig. 8. EB fluorescence leakage diagrams in rat brain under different pulse widths irradiation (color online)

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Fig. 9. BBB dose-effect relationship fitting curve

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Table 1. The relationship between field strength and irradiation distance
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Table 1. The relationship between field strength and irradiation distance
距离 / m
Distance
0.62 0.79 0.94 1.06 1.13
空间场强E_s /（kV∙m^-1）
Spatial field strength
48 40 32 24 16
脑内场强E_b /（kV∙m^-1）
Brain field strength
12 10 8 6 4

Table 2. Statistics of EB fluorescence intensity in rat brain under different field strengths irradiation
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Table 2. Statistics of EB fluorescence intensity in rat brain under different field strengths irradiation
脑内场强E_b / (kV∙m^-1)
Brain field strength
EB荧光强度
EB fluorescence intensity
对照Control 1.00±0.25
4 1.18±0.31
6 1.21±0.24
8 1.45±0.28^*
10 1.61±0.22^**
12 1.63±0.34^**

Table 3. Statistics of EB fluorescence intensity in rat brain under different number of pulses irradiation
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Table 3. Statistics of EB fluorescence intensity in rat brain under different number of pulses irradiation
脉冲个数
Number of pulses
EB荧光强度
EB fluorescence intensity
对照Control 1.00±0.26
10 1.18±0.18
20 1.61±0.22^**
50 1.58±0.24^**
100 1.62±0.30^**
200 1.64±0.38^**

Table 4. Statistics of EB fluorescence intensity in rat brain under different pulse widths irradiation
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Table 4. Statistics of EB fluorescence intensity in rat brain under different pulse widths irradiation
脉宽 / ns
Pulse width
EB荧光强度
EB fluorescence intensity
对照Control 1.00±0.26
500 1.29±0.20
750 1.61±0.22^**
1 000 1.60±0.28^**

Table 5. The relative change rate of EB content under different irradiation conditions

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Table 5. The relative change rate of EB content under different irradiation conditions

脑内场强E_b / (V∙m^-1) Brain field strength	脉冲个数 Number of pulses	脉宽 / s Pulse width	相对变化率 Relative rate of change
10 000	10	7.5×10^-7	11
10 000	20	7.5×10^-7	74
10 000	50	7.5×10^-7	83
10 000	100	7.5×10^-7	81
10 000	200	7.5×10^-7	92
10 000	20	5.0×10^-7	18
10 000	20	1.0×10^-6	68
4 000	20	7.5×10^-7	22
6 000	20	7.5×10^-7	5
8 000	20	7.5×10^-7	46
12 000	20	7.5×10^-7	70

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Jianrong HE, Xianghui WANG, Hongxin QI, Jie ZHANG. Effect of C-band pulse microwave exposure on blood-brain barrier permeability in rats[J]. Journal of Radiation Research and Radiation Processing, 2025, 43(1): 010302

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Paper Information

Category: RADIOBIOLOGY AND RADIOMEDICINE

Received: Apr. 13, 2024

Accepted: May. 10, 2024

Published Online: Mar. 13, 2025

The Author Email: ZHANG Jie (张杰)

DOI:10.11889/j.1000-3436.2024-0034

Topics

laser devices and laser physics

Lasers and Laser Optics

Laser physics

laser manufacturing

Instrumentation, Measurement and Metrology

Table 1. The relationship between field strength and irradiation distance

Table 1. The relationship between field strength and irradiation distance

Table 2. Statistics of EB fluorescence intensity in rat brain under different field strengths irradiation

Table 2. Statistics of EB fluorescence intensity in rat brain under different field strengths irradiation

Table 3. Statistics of EB fluorescence intensity in rat brain under different number of pulses irradiation

Table 3. Statistics of EB fluorescence intensity in rat brain under different number of pulses irradiation

Table 4. Statistics of EB fluorescence intensity in rat brain under different pulse widths irradiation

Table 4. Statistics of EB fluorescence intensity in rat brain under different pulse widths irradiation

Table 5. The relative change rate of EB content under different irradiation conditions

Table 5. The relative change rate of EB content under different irradiation conditions

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