Chinese Journal of Quantum Electronics, Volume. 40, Issue 3, 319(2023)

Research progress of THz-ATR technology for detecting biomedical samples

WANG Haiqing1,2 and SHI Wei1、*
Author Affiliations
  • 1Key Laboratory of Ultrafast Photoelectric Technology and Terahertz Science in Shaanxi, Xi'an University of Technology,Xi'an 710048, China
  • 2Baoji Key Laboratory of Micro-Nano Optoelectronics and Terahertz Technology, School of Physics andOpto-Electronic Technology, Baoji University of Arts and Sciences, Baoji 721016, China
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    Figures & Tables(10)
    Schematic diagram of evanescent wave generated by ATR prism
    (a) Verification model of milk fat, total solid and somatic cells[29] ; (b) THz spectra of glucose solutions with different concentrations and scatter plot between actual and predicted glucose concentrations[30]
    (a) Complex dielectric constant of sucrose aqueous solutions with different concentrations [31]; (b) Polarizability of bulk water and hydrated water [31]; (c) THz spectra of nifedipine crystals and mixtures at different concentrations [32]; (d) THz-ATR spectra of nifedipine crystals and nifedipine suspensions with different concentrations [32]
    (a) Real and imaginary parts of dielectric coefficients of distilled water, HeLa, DLD-1 and HEK293[33];(b) Average absorption spectra of ASF and FET [34]
    (a) The ATR amplitude |RP| and phase arg (Rp) of human skin at different times (0, 45, 90 min) after ingesting the glucosesolution [35]; (b) Relationship between THz- ATR spectral reflectance and theophylline concentration at 0.164 THz[36]; (c) THz timedomainwaveform, frequency spectra, dielectric constant and dielectric loss of LCIS culture solution, MCF10A cells and referenceATR prism without samples[37]; (d) The dielectric constant and dielectric loss of MCF10A living cells exposed andunexposed to 10 mmol/L H2O2 after 0, 1, 2 h were compared [37]
    (a) Refractive index and absorption coefficient and complex permittivity of artificial normal skin and melanoma samples [38] ;(b) THz absorption spectra of two short-chain oligonucleotides and two long-chain oligonucleotides withconcentrations of 5.0 g/ L and 0.5 g/L[39]
    (a) Time variation of absorption coefficient at 0.4, 1.0, 1.6 THz [40]; (b) Complex refractive index and extinction coefficient of SVG P12, HMO6 and U87 cells [41]
    (a) THz absorption spectra of colon cancer cell lines DLD-1 and HT-29 in different concentration solutions [42];(b) THz- ATR spectra of tyrosine (Tyr) enantiomers (L- and D-Tyr) and racemate (DL-Tyr) in aqueous solution [43]
    (a) Comparison of the absorption spectra of the glucose pellet, aqueous glucose (0 mg/dL versus 80 mg/dL) and smart hydrogels before and after reaching swelling equilibrium in aqueous glucose (80 mg/dL) [44]; (b) THz absorption coefficient of U87 cells treated with different concentrations of G-Rg3 for 24 hand THz absorption coefficient of U87 cells at a specific frequency [45]
    High-power THz-ATR spectra of α-lactose samples with different concentrations[46, 47]. (a) Time-domain spectra; (b) The corresponding frequency-domain spectra; (c) Characteristic absorption spectra; (d) The change rate of absorption peak position with different concentrations of α-lactose solution
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    Haiqing WANG, Wei SHI. Research progress of THz-ATR technology for detecting biomedical samples[J]. Chinese Journal of Quantum Electronics, 2023, 40(3): 319

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    Paper Information

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    Received: Mar. 1, 2023

    Accepted: --

    Published Online: Jun. 30, 2023

    The Author Email: Wei SHI (swshi@mail.xaut.edu.cn)

    DOI:10.3969/j.issn.1007-5461.2023.03.003

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