Journal of Radiation Research and Radiation Processing, Volume. 43, Issue 1, 010303(2025)

Creation of association-rule prediction model for acute radiation dermatitis in breast cancer patients

Lesha ZHU1... Zunhao ZHANG2 and Long TIAN1,* |Show fewer author(s)
Author Affiliations
  • 1Department of Radiotherapy, the First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, China
  • 2Department of Radiotherapy, the First Hospital of Hebei Medical University, Shijiazhuang 050000, China
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    Figures & Tables(4)
    Correction curve of ARD association rule prediction model (color online)
    ROC curves of ARD association rule prediction model (color online)
    • Table 1. Comparison of baseline data for the model group and validation group[n%]

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      Table 1. Comparison of baseline data for the model group and validation group[n%]

      基线资料

      Baseline data

      模型组(n=480)

      Model group (n=480)

      验证组(n=320)

      Validation group (n=320)

      χ2p

      年龄

      Age

      <40135(28.13)100(31.25)0.9040.342
      ≥40345(71.87)220(68.75)
      BMI/(kg∙m-2<28210(43.75)157(49.06)2.1820.140
      ≥28270(56.25)163(50.94)

      吸烟史

      Smoking history

      无No418(87.08)290(90.63)2.3660.124
      有Yes62(12.92)30(9.37)

      饮酒史

      Drinking history

      无No447(93.13)300(93.75)0.1210.727
      有Yes33(6.87)20(6.25)

      糖尿病史

      Diabetes history

      无No388(80.83)271(84.69)1.9640.161
      有Yes92(19.17)49(15.31)

      高血压史

      Hypertension history

      无No378(78.75)239(74.69)1.7960.180
      有Yes102(21.25)81(25.31)

      免疫功能缺陷史

      Immune dysfunction history

      无No468(97.50)314(98.13)0.3410.559
      有Yes12(2.50)6(1.87)

      血清白蛋白水平/(g∙L-1

      Serum albumin level

      <45155(32.29)110(34.37)0.3760.540
      ≥45325(67.71)210(65.63)

      白细胞计数/(109∙L-1

      White blood cell count

      <6398(82.92)260(81.25)0.3650.546
      ≥682(17.08)60(18.75)

      肿瘤分期

      Tumor stage

      343(71.46)242(75.63)1.6960.193
      137(28.54)78(24.37)

      化疗史

      Chemotherapy history

      无No78(16.25)42(13.12)1.4710.225
      有Yes402(83.75)278(86.88)

      平均照射野面积/cm2

      Average irradiation field area

      <15158(32.92)110(34.38)0.1830.669
      ≥15322(67.08)210(65.62)

      子野数量

      Number of subfield

      <65176(36.67)105(32.81)1.2520.263
      ≥65304(63.33)215(67.19)

      放疗总时长/min

      Total radiotherapy duration

      <45168(35.00)114(35.63)0.0330.856
      ≥45312(65.00)206(64.37)

      ARD情况

      ARD situation

      无No116(24.17)70(21.88)0.5650.452
      有Yes364(75.83)250(78.12)
    • Table 2. Association rule prediction model for ARD

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      Table 2. Association rule prediction model for ARD

      序号

      No.

      前项

      First item

      后项

      Second item

      SCL
      1BMI≥28 kg/m2

      ARD(有)

      ARD(Yes)

      0.390.422.61
      2

      血清白蛋白水平<45 g/L

      Serum albumin level <45 g/L

      ARD(有)

      ARD(Yes)

      0.460.482.84
      3

      化疗史(有)

      Chemotherapy history(Yes)

      ARD(有)

      ARD(Yes)

      0.440.452.73
      4

      平均照射野面积≥15 cm2

      Average irradiation field area ≥15 cm2

      ARD(有)

      ARD(Yes)

      0.490.512.98
      5

      血清白蛋白水平<45 g/L、平均照射野面积≥15 cm2

      Serum albumin level <45 g/L, average irradiation field area ≥15 cm2

      ARD(有)

      ARD(Yes)

      0.620.663.11
      6

      化疗史(有)、平均照射野面积≥15 cm2

      Chemotherapy history(Yes), average irradiation field area ≥15 cm2

      ARD(有)

      ARD(Yes)

      0.570.602.99
      7

      BMI≥28 kg/m2、血清白蛋白水平<45 g/L、平均照射野面积≥15 cm2

      BMI≥28 kg/m2, serum albumin level <45 g/L, average irradiation field area ≥15 cm2

      ARD(有)

      ARD(Yes)

      0.630.683.08
      8

      血清白蛋白水平<45 g/L、化疗史(有)、平均照射野面积≥15 cm2

      Serum albumin level <45 g/L, chemotherapy history(Yes),

      average irradiation field area ≥15 cm2

      ARD(有)

      ARD(Yes)

      0.690.733.16
      9

      BMI≥28 kg/m2、血清白蛋白水平<45 g/L、化疗史(有)、平均照射野面积≥15 cm2

      BMI≥28 kg/m2, serum albumin level <45 g/L, chemotherapy history(Yes),

      average irradiation field area ≥15 cm2

      ARD(有)

      ARD(Yes)

      0.730.773.25
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    Lesha ZHU, Zunhao ZHANG, Long TIAN. Creation of association-rule prediction model for acute radiation dermatitis in breast cancer patients[J]. Journal of Radiation Research and Radiation Processing, 2025, 43(1): 010303

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    Paper Information

    Category: RADIOBIOLOGY AND RADIOMEDICINE

    Received: Jul. 10, 2024

    Accepted: Nov. 15, 2024

    Published Online: Mar. 13, 2025

    The Author Email: TIAN Long (田龙)

    DOI:10.11889/j.1000-3436.2024-0061

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