Effect of different physics lists in Monte Carlo simulation on proton boron capture therapy

Junxiang Wu; Liyuan Deng; Zhencen He; Zhao Sun; Zhimin Hu

doi:10.11884/HPLPB202436.240019

High Power Laser and Particle Beams, Volume. 36, Issue 6, 066002(2024)

Effect of different physics lists in Monte Carlo simulation on proton boron capture therapy

Junxiang Wu1...2, Liyuan Deng1, Zhencen He1, Zhao Sun1 and Zhimin Hu1,* |Show fewer author(s)

¹Key Laboratory of Radiation Physics and Technology of the Ministry of Education/Institute of Nuclear Science and Technology, Sichuan University, Chengdu 610064, China

²Radiation Oncology Department Sichuan Cancer Hospital and Institute, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu 610041, China

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Figures & Tables(8)

Fig. 1. Nuclear reaction of PBCT flow chart

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Fig. 2. Schematic overview of the Geant4 simulation

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Fig. 3. PDD of three physics lists in this study and compared with Yoon, et al

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Fig. 4. Relative energy deposition curves for proton beam with and without boron region of three physics lists

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Fig. 5. LDP curves for proton beam with and without boron region of three physics lists

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Table 1. Composition of material in MC
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Table 1. Composition of material in MC
material w_B/% w_H/% w_O/% w_C/% w_N/% w_Ar/% density/(g·cm⁻³)
boron 100 − − − − − 2.08
water − 11.19 88.81 − − − 1
air − − 23.18 0.02 75.52 1.28 1.205×10⁻³
vacuum − − − − − − 1.0×10⁻²⁵

Table 2. Physics models and reaction cross-section of three physics lists

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Table 2. Physics models and reaction cross-section of three physics lists

physics list	type of modules		models (particle and energy ranges)	cross-sections
FTFP_BERT	hadron physics	inelastic model	Fritiof parton (FTF) (p,n, 3 GeV～100 TeV)	p (G4BGGNucleonInelasticXS) n (G4NeutronInelasticXS)
		inelastic model	Bertini intranuclear cascade (p,n, 0～6 GeV）	p (G4BGGNucleonInelasticXS) n (G4NeutronInelasticXS)
		elastic model	G4ChipsElasticModel(p,n, 0～100 TeV)	p (G4BGGNucleonElasticXS)n (G4NeutronElasticXS)
	electromagnetic physics		G4EmStandardPhysics (γ,e⁻)	−
QBBC	hadron physics	inelastic model	Fritiof parton (FTF) (p,n, 3 GeV～100 TeV)	p (G4ParticleInelasticXS)n (G4NeutronInelasticXS)
			Binary cascade (p,n, 0～1.5 GeV）
			Bertini (p,n, 1～6 GeV）
		elastic model	G4ChipsElasticModel(p,n, 0～100 TeV)	p (G4BGGNucleonElasticXS)n (G4NeutronElasticXS)
	electromagnetic physics		G4EmStandardPhysics (γ,e⁻)	−
QGSP_BIC_AllHP	hadron physics	inelastic model	Binary cascade (p,n, 0～6 GeV）	p ≥20 MeV(G4BGGNucleonInelasticXS)n (G4NeutronInelasticXS)
			Quark-gluon String (QGS)(p,n, ＞12 GeV）
			Fritiof parton (FTF) (p,n, 3～25 GeV)
		elastic model	G4ChipsElasticModel(p,n, 0～100 TeV)	p (G4BGGNucleonElasticXS)n (G4NeutronElasticXS)
	electromagnetic physics		G4EmStandardPhysics4 (γ,e⁻)	−

Table 3. Nuclear reaction product data of PBCT with three physics lists
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Table 3. Nuclear reaction product data of PBCT with three physics lists
physics list energy/MeV yield of α/% mean energy of α/MeV energy range of α//MeV
FTFP_BERT 3 0.1 4.51 0.11～9.16
QBBC 3 7.6 4.17 0.35～9.23
QGSP_BIC_AllHP 3 3.2 5.59 0.01～9.58

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Junxiang Wu, Liyuan Deng, Zhencen He, Zhao Sun, Zhimin Hu. Effect of different physics lists in Monte Carlo simulation on proton boron capture therapy[J]. High Power Laser and Particle Beams, 2024, 36(6): 066002

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