Chinese Optics Letters, Volume. 20, Issue 1, 011701(2022)

Dual-beam delay-encoded all fiber Doppler optical coherence tomography for in vivo measurement of retinal blood flow

Mingming Wan1, Shanshan Liang2、**, Xinyu Li3, Zhengyu Duan4, Jiebin Zou1, Jun Chen1,5, Jin Yuan6, and Jun Zhang7、*
Author Affiliations
  • 1School of Electronics and Information Technology, Sun Yat-sen University, Guangzhou 510006, China
  • 2National Innovation Center for Advanced Medical Devices, Shenzhen 518131, China
  • 3GBA Branch of Aerospace Information Research Institute, Chinese Academy of Sciences, Guangzhou 510530, China
  • 4School of Biomedical Engineering, Sun Yat-sen University, Guangzhou 510006, China
  • 5State Key Laboratory of Optoelectronic Materials and Technologies, School of Electronics and Information Technology, Sun Yat-sen University, Guangzhou 510275, China
  • 6State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China
  • 7School of Artificial Intelligence, Guilin University of Electronic Technology, Guilin 541004, China
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    Figures & Tables(5)
    Schematic of the dual-beam delay-encoded fiber-based DOCT system. L1–L10, lens; L11, cylindrical lens; M1, mirror; M2, strip mirror; D1, D2, dichroic mirror; C1, C2, line scan camera; FC, fiber coupler; PC, polarization controller; F, fixation screen; GP, glass plate; BD, beam displacer; LD, 780 nm laser diode; LSLO, line scanning laser ophthalmoscopy system; SLD, superluminescent diode.
    Illustration of the incident probe beams and the blood flow velocity. V, direction of the blood flow velocity; P1 and P2, two probe beams; Δα, angle between the two probe beams; β, angle between V and the illumination plane (y–z plane, composed of P1 and P2).
    Illustration of the illumination plane and scanning track. V, direction of the blood flow velocity; L, scanning track of OCT beams on the retina.
    (a) Measured blood flow at the set blood flow of 20 µL/min as a function of the sampling step. (b) Measured blood flow versus the set blood flow.
    Retinal blood flow imaging with the DDD-OCT system. (a) LSLO fundus view. The black line marks the scanning track. V1, an artery vessel. (b) Structural and (c) Doppler OCT images of the vessel V1. (d) Absolute velocity of the blood flow in V1 as a function of time.
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    Mingming Wan, Shanshan Liang, Xinyu Li, Zhengyu Duan, Jiebin Zou, Jun Chen, Jin Yuan, Jun Zhang. Dual-beam delay-encoded all fiber Doppler optical coherence tomography for in vivo measurement of retinal blood flow[J]. Chinese Optics Letters, 2022, 20(1): 011701

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    Paper Information

    Category: Biophotonics

    Received: Sep. 2, 2021

    Accepted: Oct. 14, 2021

    Published Online: Nov. 11, 2021

    The Author Email: Shanshan Liang (ss.liang@nmed.org.cn), Jun Zhang (junzhang8819@gmail.com)

    DOI:10.3788/COL202220.011701

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