In the visual servo process, the quadrotor UAV is prone to be interfered.To solve the problem, a nonlinear anti-disturbance controller for image-based visual servo control of the quadrotor UAV is designed by using an integral backstepping sliding mode control method.Image moments are chosen as features.The virtual camera plane is used to improve the dynamic model in the presence of model uncertainties and external disturbances.As for the linear velocity of virtual plane that is hard to measure directly, a linear velocity estimator is designed by using the backstepping method to improve the accuracy of control.The stability of the proposed global integral backstepping sliding mode controller is proved by using Lyapunov theory.The simulation experiment results demonstrate the effectiveness and robustness of the designed controller.