Fig. 1. Endocytoscopy system with high magnification

Fig. 2. Observation on stained nuclei of esophageal mucosa tissue of pig by endocytoscopy system with high magnification

Fig. 3. Structure of nuclear segmentation model based on FCN

Fig. 4. Nuclear label

Fig. 5. Comparison of segmentation results of three methods

Fig. 6. Segmentation results of FCN-crop model. （a）-（c） are original images， and （e）-（f） are segmentation results