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Laser & Optoelectronics Progress, Volume. 55, Issue 3, 030004(2018)

Application of Illegal Drugs Detection Based on Surface Enhanced Raman Spectroscopy

Shuhua Lu1,2、*, Zhaoming Wang1, and Fang Tian1
Author Affiliations
  • 1 School of Information Technology and Cyber Security, People's Public Security University of China, Beijing 102623, China
  • 2 Key Laboratory of Security Technology and Risk Assessment, Ministry of Public Security, People's Public Security University of China, Beijing 102623, China
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    AbstractGet PDF(in Chinese)
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    Figures & Tables(6)
    Molecular structure of several common illegal drugs

    Fig. 1. Molecular structure of several common illegal drugs

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    Combination of microfluidic device and SERS for detection of drugs in saliva. (a) Ag nanoparticle suspension, saliva, and salt solution are loaded into microfluidic device by vacuum pump; (b) sample stream is enveloped by side-streams at flow-focusing junction and diffusion drives lateral mass transport between laminar flows; (c) schematic of Ag nanoparticles, analyte, and salt solution are introduced to the channel from the left and flow toward the right[5]

    Fig. 2. Combination of microfluidic device and SERS for detection of drugs in saliva. (a) Ag nanoparticle suspension, saliva, and salt solution are loaded into microfluidic device by vacuum pump; (b) sample stream is enveloped by side-streams at flow-focusing junction and diffusion drives lateral mass transport between laminar flows; (c) schematic of Ag nanoparticles, analyte, and salt solution are introduced to the channel from the left and flow toward the right[5]

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    (a) Schematic of self-assembly of Ag NPs into spherical Ag colloidal superstructures; (b) schematic of SERS platform for sensing analytes located in 3D geometrical gaps of colloidal superstructure[11]

    Fig. 3. (a) Schematic of self-assembly of Ag NPs into spherical Ag colloidal superstructures; (b) schematic of SERS platform for sensing analytes located in 3D geometrical gaps of colloidal superstructure[11]

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    Comparison of drugs detection in urine. (a) Standard detection procedure; (b) combination of D-SERS and SVM[6]

    Fig. 4. Comparison of drugs detection in urine. (a) Standard detection procedure; (b) combination of D-SERS and SVM[6]

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    Space distribution of SERS spectra of three kinds of drug abusers'urine samples containing MAMP mass fraction of 3×10-5, 3×10-6, and 4×10-7 (dotted line represents boundary of urine with or without MAMP)[6]

    Fig. 5. Space distribution of SERS spectra of three kinds of drug abusers'urine samples containing MAMP mass fraction of 3×10-5, 3×10-6, and 4×10-7 (dotted line represents boundary of urine with or without MAMP)[6]

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    • Table 1. SERS detection parameters of illegal drugs reported in literatures

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      Table 1. SERS detection parameters of illegal drugs reported in literatures

      aDrugbSubstrateWavelength oflaser /nmLODRamanshift /cm-1Reference
      CocaineAu or Ag sol-gels7855×10-11999[31]
      CocaineFused Au colloids78550 μg·L-1(in saliva)999,1018,1107,1578,1593[32]
      Cocaine HClMetastable Ag NPs514.510-8 mol·L-1860,1006,1275,1450,1594[33]
      CodeineAg NPs6330.7 μmol·L-1 (in water),1.39 μmol·L-1(in plasma)637,771,1131,1281,1684,2953,3028,3031,3059[8]
      BZEAu dotted magnetic NCs7852.9×10-11 (in saliva)996,1020[13]
      Ketamine HClAg nanoneedles6332.7×10-11458,593,654,1023,1048,1156,1450,1593,1721[7]
      BZEAg-coated CNTs7851 nmol·L-1764,812,866,968,1031,1313,1440,1581[14]
      MDMAAgNPs785<5×10-5716,772,812,1252[15]
      MorphineAg sols7851.5 μg·L-1401,451,492,557,647,720,807,872,953,1032,1093,1129,1190,1248,1273,1331,1424,1467,1572[34]
      MAUC@SiO2@Ag78510-7 mol·L-11002,1030,1206[17]
      MAMP/AMPAg nanorods78550 μg·L-1619,742,824,997,1027,1202[19]
      AMPR/E Ag foil6471.9×10-5998,1055,1125,1205,1223,1389,1569[28]
      MAMPR/E Ag foil6471.7×10-51000,1058,1126,1219,1389,572[28]
      MAMP3D Ag superstructures53210-12 (in aqueous),10-11 ( in urine)620,750,834,1001,1206,620,1001,1205,1030,834[11]
      MAMPAg NPs with MFD63310 nmol·L-11004,1030,1219,1600[5]
      MephedroneAg NPs6331.6 mg·L-1797,969,1034,1184,1212,1356,1606,1678,2922,3059[35]
      α-HADAg/Au core/shell8300.29 mg·L-1686,1000,1158,1304,1595[4]
      ButalbitalAg/Au core/shell8300.26 mg·L-1500,617,645,841,925,1040,1140,1300,1410,1642, 1726,1746[4]
      BZEAg/Au core/shell8300.09 mg·L-1650,1000,1020,1595,1650,1715,1730[4]
      PDEAg/Au core/shell8300.39 mg·L-1618,753,834,910,1002,1025,1173,1208,1334,1390,1462,1603[4]
      JWH-018Au NPs78518 μg·L-1-[18]
      JWH-073Au NPs78551 μg·L-1-[18]
      JWH-081Au NPs78518 μg·L-1-[18]
      JWH-122Au NPs78542 μg·L-1-[18]
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    Shuhua Lu, Zhaoming Wang, Fang Tian. Application of Illegal Drugs Detection Based on Surface Enhanced Raman Spectroscopy[J]. Laser & Optoelectronics Progress, 2018, 55(3): 030004

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    Paper Information

    Category: General

    Received: Aug. 30, 2017

    Accepted: --

    Published Online: Sep. 10, 2018

    The Author Email: Lu Shuhua (luhua1021@126.com)

    DOI:10.3788/LOP55.030004

    Topics

    laser devices and laser physics
    Lasers and Laser Optics
    Laser physics
    laser manufacturing
    Instrumentation, Measurement and Metrology