[1] H. Sung, J. Ferlay, R. L. Siegel, M. Laversanne, I. Soerjomataram, A. Jemal, F. Bray. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin., 71, 209-249(2021).

[2] C. Xia, X. Dong, H. Li, M. Cao, D. Sun, S. He, F. Yang, X. Yan, S. Zhang, N. Li, W. Chen. Cancer statistics in China and United States, 2022: Profiles, trends, and determinants. Chin. Med. J. (Engl)., 135, 584-590(2022).

[3] L. Kulik, J. K. Heimbach, F. Zaiem, J. Almasri, L. J. Prokop, Z. Wang, M. H. Murad, K. Mohammed. Therapies for patients with hepatocellular carcinoma awaiting liver transplantation: A systematic review and meta-analysis. Hepatology, 67, 381-400(2018).

[4] T. Ishizawa, N. Fukushima, J. Shibahara, K. Masuda, S. Tamura, T. Aoki, K. Hasegawa, Y. Beck, M. Fukayama, N. Kokudo. Real-time identification of liver cancers by using indocyanine green fluorescent imaging. Cancer, 115, 2491-2504(2009).

[5] A. L. Vahrmeijer, M. Hutteman, J. R. van der Vorst, C. J. van de Velde, J. V. Frangioni. Image-guided cancer surgery using near-infrared fluorescence. Nat. Rev. Clin. Oncol., 10, 507-518(2013).

[6] Q. Y. Chen, J. W. Xie, Q. Zhong, J. B. Wang, J. X. Lin, J. Lu, L. L. Cao, M. Lin, R. H. Tu, Z. N. Huang, J. L. Lin, H. L. Zheng, P. Li, C. H. Zheng, C. M. Huang. Safety and efficacy of indocyanine green tracer-guided lymph node dissection during laparoscopic radical gastrectomy in patients with gastric cancer: A randomized clinical trial. JAMA Surg., 155, 300-311(2020).

[7] R. R. Zhang, A. B. Schroeder, J. J. Grudzinski, E. L. Rosenthal, J. M. Warram, A. N. Pinchuk, K. W. Eliceiri, J. S. Kuo, J. P. Weichert. Beyond the margins: Real-time detection of cancer using targeted fluorophores. Nat. Rev. Clin. Oncol., 14, 347-364(2017).

[8] N. Yokoyama, T. Otani, H. Hashidate, C. Maeda, T. Katada, N. Sudo, S. Manabe, Y. Ikeno, A. Toyoda, N. Katayanagi. Real-time detection of hepatic micrometastases from pancreatic cancer by intraoperative fluorescence imaging: Preliminary results of a prospective study. Cancer, 118, 2813-2819(2012).

[9] K. He, X. Hong, C. Chi, C. Cai, K. Wang, P. Li, X. Liu, J. Li, H. Shan, J. Tian. A new method of near-infrared fluorescence image-guided hepatectomy for patients with hepatolithiasis: A randomized controlled trial. Surg. Endosc., 34, 4975-4982(2020).

[10] Kenry, Y. Duan, B. Liu. Recent advances of optical imaging in the second near-infrared window. Adv. Mater., 30, e1802394(2018).

[11] Y. Sun, M. Ding, X. Zeng, Y. Xiao, H. Wu, H. Zhou, B. Ding, C. Qu, W. Hou, A. Er-Bu, Y. Zhang, Z. Cheng, X. Hong. Novel bright-emission small-molecule NIR-II fluorophores for in vivo tumor imaging and image-guided surgery. Chem. Sci., 8, 3489-3493(2017).

[12] S. Zhu, S. Herraiz, J. Yue, M. Zhang, H. Wan, Q. Yang, Z. Ma, Y. Wang, J. He, A. L. Antaris, Y. Zhong, S. Diao, Y. Feng, Y. Zhou, K. Yu, G. Hong, Y. Liang, A. J. Hsueh, H. Dai. 3D NIR-II molecular imaging distinguishes targeted organs with high-performance NIR-II bioconjugates. Adv. Mater., 30, e1705799(2018).

[13] M. L. Landsman, G. Kwant, G. A. Mook, W. G. Zijlstra. Light-absorbing properties, stability, and spectral stabilization of indocyanine green. J. Appl. Physiol., 40, 575-583(1976).

[14] A. Miyata, T. Ishizawa, K. Tani, A. Shimizu, J. Kaneko, T. Aoki, Y. Sakamoto, Y. Sugawara, K. Hasegawa, N. Kokudo. Reappraisal of a dye-staining technique for anatomic hepatectomy by the concomitant use of indocyanine green fluorescence imaging. J. Am. Coll. Surg., 221, e27-e36(2015).

[15] T. Ishizawa, Y. Bandai, M. Ijichi, J. Kaneko, K. Hasegawa, N. Kokudo. Fluorescent cholangiography illuminating the biliary tree during laparoscopic cholecystectomy. Br. J. Surg., 97, 1369-1377(2010).

[16] Y. M. Zhang, R. Shi, J. C. Hou, Z. R. Liu, Z. L. Cui, Y. Li, D. Wu, Y. Shi, Z. Y. Shen. Liver tumor boundaries identified intraoperatively using real-time indocyanine green fluorescence imaging. J. Cancer Res. Clin. Oncol., 143, 51-58(2017).

[17] H. Kudo, T. Ishizawa, K. Tani, N. Harada, A. Ichida, A. Shimizu, J. Kaneko, T. Aoki, Y. Sakamoto, Y. Sugawara, K. Hasegawa, N. Kokudo. Visualization of subcapsular hepatic malignancy by indocyanine-green fluorescence imaging during laparoscopic hepatectomy. Surg. Endosc., 28, 2504-2508(2014).

[18] K. He, X. Hong, C. Chi, C. Cai, Y. An, P. Li, X. Liu, H. Shan, J. Tian, J. Li. Efficacy of near-infrared fluorescence-guided hepatectomy for the detection of colorectal liver metastases: A randomized controlled trial. J. Am. Coll. Surg., 234, 130-137(2022).

[19] G. Hong, A. Antaris, H. Dai. Near-infrared fluorophores for biomedical imaging. Nat. Biomed. Eng., 1, 0010(2017).

[20] K. Cheng, H. Chen, C. H. Jenkins, G. Zhang, W. Zhao, Z. Zhang, F. Han, J. Fung, M. Yang, Y. Jiang, L. Xing, Z. Cheng. Synthesis, characterization, and biomedical applications of a targeted dual-modal near-infrared-II fluorescence and photoacoustic imaging nanoprobe. ACS Nano., 11, 12276-12291(2017).

[21] B. Li, L. Lu, M. Zhao, Z. Lei, F. Zhang. An efficient 1064 nm NIR-II excitation fluorescent molecular dye for deep-tissue high-resolution dynamic bioimaging. Angew. Chem. Int. Ed. Engl., 57, 7483-7487(2018).

[22] S. He, J. Song, J. Qu, Z. Cheng. Crucial breakthrough of second near-infrared biological window fluorophores: Design and synthesis toward multimodal imaging and theranostics. Chem. Soc. Rev., 47, 4258-4278(2018).

[23] A. L. Antaris, H. Chen, K. Cheng, Y. Sun, G. Hong, C. Qu, S. Diao, Z. Deng, X. Hu, B. Zhang, X. Zhang, O. K. Yaghi, Z. R. Alamparambil, X. Hong, Z. Cheng, H. Dai. A small-molecule dye for NIR-II imaging. Nat. Mater., 15, 235-242(2016).

[24] J. T. Robinson, G. Hong, Y. Liang, B. Zhang, O. K. Yaghi, H. Dai. In vivo fluorescence imaging in the second near-infrared window with long circulating carbon nanotubes capable of ultrahigh tumor uptake. J. Am. Chem. Soc., 134, 10664-10669(2012).

[25] A. L. Antaris, H. Chen, S. Diao, Z. Ma, Z. Zhang, S. Zhu, J. Wang, A. X. Lozano, Q. Fan, L. Chew, M. Zhu, K. Cheng, X. Hong, H. Dai, Z. Cheng. A high quantum yield molecule-protein complex fluorophore for near-infrared II imaging. Nat. Commun., 8, 15269(2017).

[26] S. Zhu, B. C. Yung, S. Chandra, G. Niu, A. L. Antaris, X. Chen. Near-infrared-II (NIR-II) bioimaging via off-peak NIR-I fluorescence emission. Theranostics, 8, 4141-4151(2018).

[27] S. Zhu, Z. Hu, R. Tian, B. C. Yung, Q. Yang, S. Zhao, D. O. Kiesewetter, G. Niu, H. Sun, A. L. Antaris, X. Chen. Repurposing cyanine NIR-I dyes accelerates clinical translation of near-infrared-II (NIR-II) bioimaging. Adv. Mater., 30, e1802546(2018).

[28] Z. Starosolski, R. Bhavane, K. B. Ghaghada, S. A. Vasudevan, A. Kaay, A. Annapragada. Indocyanine green fluorescence in second near-infrared (NIR-II) window. PLoS One, 12, e0187563(2017).

[29] Z. Hu, C. Fang, B. Li, Z. Zhang, C. Cao, M. Cai, S. Su, X. Sun, X. Shi, C. Li, T. Zhou, Y. Zhang, C. Chi, P. He, X. Xia, Y. Chen, S. S. Gambhir, Z. Cheng, J. Tian. First-in-human liver-tumour surgery guided by multispectral fluorescence imaging in the visible and near-infrared-I/II windows. Nat. Biomed. Eng., 4, 259-271(2020).

[30] H. Shi, L. V. Huttad, M. Tan, H. Liu, M. S. Chua, Z. Cheng, S. So. NIR-II imaging of hepatocellular carcinoma based on a humanized anti-GPC3 antibody. RSC Med Chem., 13, 90-97(2021).

[31] Z. Zhang, C. Fang, Y. Zhang, S. Su, B. Li, G. Liu, Z. Hu, J. Tian. NIR-II nano fluorescence image guided hepatic carcinoma resection on cirrhotic patient. Photodiagn. Photodyn. Ther., 40, 103098(2022).

[32] F. Ding, C. Li, Y. Xu, J. Li, H. Li, G. Yang, Y. Sun. PEGylation regulates self-assembled small-molecule dye-based probes from single molecule to nanoparticle size for multifunctional NIR-II bioimaging. Adv. Healthc. Mater., 7, e1800973(2018).

[33] Q. Li, J. B. White, N. C. Peterson, K. W. Rickert, C. O. Lloyd, K. L. Allen, K. Rosenthal, X. Gao, H. Wu, W. F. Dall’Acqua, M. J. Borrok, P. Tsui. Tumor uptake of pegylated diabodies: Balancing systemic clearance and vascular transport. J. Control. Release, 279, 126-135(2018).

[34] H. Lou, A. Ji, C. Qu, S. Duan, H. Liu, H. Chen, Z. Cheng. A novel NIR-II nanoprobe for precision imaging of micro-meter sized tumor metastases of multi-organs and skin flap. Chem. Eng. J., 449, 137848(2022).

[35] T. Ai, W. Shang, H. Yan, C. Zeng, K. Wang, Y. Gao, T. Guan, C. Fang, J. Tian. Near infrared-emitting persistent luminescent nanoparticles for hepatocellular carcinoma imaging and luminescence-guided surgery. Biomaterials, 167, 216-225(2018).

[36] Y. Jin, K. Wang, J. Tian. Preoperative examination and intraoperative identification of hepatocellular carcinoma using a targeted bimodal imaging probe. Bioconjug. Chem., 29, 1475-1484(2018).

[37] Z. Zeng, J. Ouyang, L. Sun, C. Zeng, F. Zeng, S. Wu. Activatable nanocomposite probe for preoperative location and intraoperative navigation for orthotopic hepatic tumor resection via MSOT and aggregation-induced near-IR-I/II fluorescence imaging. Anal. Chem., 92, 9257-9264(2020).

[38] J. Y. Xie, C. Y. Li, Y. F. Li, J. Fei, F. Xu, J. Ou-Yang, J. Liu. Near-infrared fluorescent probe with high quantum yield and its application in the selective detection of glutathione in living cells and tissues. Anal. Chem., 88, 9746-9752(2016).

[39] Y. Ren, S. He, L. Huttad, M. S. Chua, S. K. So, Q. Guo, Z. Cheng. An NIR-II/MR dual modal nanoprobe for liver cancer imaging. Nanoscale, 12, 11510-11517(2020).

[40] S. He, S. Chen, D. Li, Y. Wu, X. Zhang, J. Liu, J. Song, L. Liu, J. Q, Z. Cheng. High affinity to skeleton rare earth doped nanoparticles for near-infrared II imaging. Nano Lett., 19, 2985-2992(2019).

[41] Y. Sun, X. Zeng, Y. Xiao, C. Liu, H. Zhu, H. Zhou, Z. Chen, F. Xu, J. Wang, M. Zhu, J. Wu, M. Tian, H. Zhang, Z. Deng, Z. Cheng, X. Hong. Novel dual-function near-infrared II fluorescence and PET probe for tumor delineation and image-guided surgery. Chem. Sci., 9, 2092-2097(2018).

[42] M. Zhao, B. Li, Y. Wu, H. He, X. Zhu, H. Zhang, C. Dou, L. Feng, Y. Fan, F. Zhang. A tumor-microenvironment-responsive lanthanide-cyanine FRET sensor for NIR-II luminescence-lifetime in situ imaging of hepatocellular carcinoma. Adv. Mater., 32, e2001172(2020).

[43] X. Ai, Z. Wang, H. Cheong, Y. Wang, R. Zhang, J. Lin, Y. Zheng, M. Gao, B. Xing. Multispectral optoacoustic imaging of dynamic redox correlation and pathophysiological progression utilizing upconversion nanoprobes. Nat. Commun., 10, 1087(2019).

[44] C. Szabó, H. Ischiropoulos, R. Radi. Peroxynitrite: Biochemistry, pathophysiology and development of therapeutics. Nat. Rev. Drug Discov., 6, 662-680(2007).

[45] R. Jia, H. Xu, C. Wang, L. Su, J. Jing, S. Xu, Y. Zhou, W. Sun, J. Song, X. Chen, H. Chen. NIR-II emissive AIEgen photosensitizers enable ultrasensitive imaging-guided surgery and phototherapy to fully inhibit orthotopic hepatic tumors. J. Nanobiotechnol., 19, 419(2021).

[46] Z. Sheng, B. Guo, D. Hu, S. Xu, W. Wu, W. H. Liew, K. Yao, J. Jiang, C. Liu, H. Zheng, B. Liu. Bright aggregation-induced-emission dots for targeted synergetic NIR-II fluorescence and NIR-I photoacoustic imaging of orthotopic brain tumors. Adv. Mater., e1800766(2018).

[47] H. Dang, Y. Tian, Q. Cheng, C. Teng, K. Xie, L. Yan. Galactose conjugated boron dipyrromethene and hydrogen bonding promoted J-aggregates for efficiently targeted NIR-II fluorescence assistant photothermal therapy. J. Colloid Interface Sci., 612, 287-297(2022).

[48] S. Li, Y. Zhang, X. Liu, Y. Tian, Y. Cheng, L. Tang, H. Lin. Smart NIR-II croconaine dye-peptide for enhanced photo-sonotheranostics of hepatocellular carcinoma. Theranostics, 12, 76-86(2022).

[49] H. Feng, L. C. Yan, Z. Y. Jun, W. Mao, W. D. Ming, W. Q. Bin. Real-time in vivo visualization of tumor therapy by a near-infrared-II Ag2S quantum dot-based theranostic nanoplatform. Nano Res., 8, 1637-1647(2015).

[50] N. Liao, L. Su, Y. Zheng, B. Zhao, M. Wu, D. Zhang, H. Yang, X. Liu, J. Song. In vivo tracking of cell viability for adoptive natural killer cell-based immunotherapy by ratiometric NIR-II fluorescence imaging. Angew. Chem. Int. Ed. Engl., 60, 20888-20896(2021).

[51] M. Neve Polimeno, C. Ierano, C. D’Alterio, N. Simona Losito, M. Napolitano, L. Portella, G. Scognamiglio, F. Tatangelo, A. Maria Trotta, S. Curley, S. Costantini, R. Liuzzi, F. Izzo, S. Scala. CXCR4 expression affects overall survival of HCC patients whereas CXCR7 expression does not. Cell. Mol. Immunol., 12, 474-482(2015).

[52] F. Zhou, W. Shang, X. Yu, J. Tian. Glypican-3: A promising biomarker for hepatocellular carcinoma diagnosis and treatment. Med. Res. Rev., 38, 741-767(2018).

[53] Y. R. Kim, M. R. Byun, J. W. Choi. Integrin α6 as an invasiveness marker for hepatitis B viral X-driven hepatocellular carcinoma. Cancer Biomark., 23, 135-144(2018).

[54] S. Jeong, J. Song, W. Lee, Y. M. Ryu, Y. Jung, S. Y. Kim, K. Kim, S. C. Hong, S. J. Myung, S. Kim. Cancer-microenvironment-sensitive activatable quantum dot probe in the second near-infrared window. Nano Lett., 17, 1378-1386(2017).

[55] G. Xu, Q. Yan, X. Lv, Y. Zhu, K. Xin, B. Shi, R. Wang, J. Chen, W. Gao, P. Shi, C. Fan, C. Zhao, H. Tian. Imaging of colorectal cancers using activatable nanoprobes with second near-infrared window emission. Angew. Chem. Int. Ed. Engl., 57, 3626-3630(2018).

[56] K. Pu, A. J. Shuhendler, J. V. Jokerst, J. Mei, S. S. Gambhir, Z. Bao, J. Rao. Semiconducting polymer nanoparticles as photoacoustic molecular imaging probes in living mice. Nat. Nanotechnol., 9, 233-239(2014).

[57] Y. Tang, Y. Li, X. Hu, H. Zhao, Y. Ji, L. Chen, W. Hu, W. Zhang, X. Li, X. Lu, W. Huang, Q. Fan. “Dual lock-and-key”-controlled nanoprobes for ultrahigh specific fluorescence imaging in the second near-infrared window. Adv. Mater., 30, e1801140(2018).

[58] A. Yuan, W. Huan, X. Liu, Z. Zhang, Y. Zhang, J. Wu, Y. Hu. NIR light-activated drug release for synergetic chemo-photothermal therapy. Mol. Pharm., 14, 242-251(2017).

[59] M. Li, H. Yan, C. Teh, V. Korzh, Y. Zhao. NIR-triggered drug release from switchable rotaxane-functionalized silica-covered Au nanorods. Chem. Commun. (Camb.), 50, 9745-9748(2014).

[60] L. Li, C. Shao, T. Liu, Z. Chao, H. Chen, F. Xiao, H. He, Z. Wei, Y. Zhu, H. Wang, X. Zhang, Y. Wen, B. Yang, F. He, L. Tian. An NIR-II-emissive photosensitizer for hypoxia-tolerant photodynamic theranostics. Adv. Mater., 32, e2003471(2020).

[61] Q. Xie, J. Liu, B. Chen, X. Ge, X. Zhang, S. Gao, Q. Ma, J. Song. NIR-II fluorescent activatable drug delivery nanoplatform for cancer-targeted combined photodynamic and chemotherapy. ACS Appl. Bio Mater., 5, 711-722(2022).