Journal of Innovative Optical Health Sciences, Volume. 14, Issue 4, 2141003(2021)
Construction of Au@Metal-organic framework for sensitive determination of creatinine in urine
Creatinine level in urine is an important biomarker for renal function diseases, such as renal failure, glomerulonephritis, and chronic nephritis. The Au@MIL-101(Fe) was prepared by in situ growth of Au nanoparticles in MIL-101(Fe) as a selective SERS substrate. The Au@MIL-101(Fe) offers the great local surface plasmon resonance (SPR) effect due to gold nanoparticles aggregation inside metal-organic frameworks. The framework structure could enrich trace target samples and drag them into SPR hot spots. The optimal Au@MIL-101(Fe) composite substrate is used for analyzing creatinine in urine and the limit of detection is down to 0.1 μmol/L and a linear relationship is ranging from 1 μmol/L to 100 μmol/L.
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Yuning Jiang, Yanzheng Cai, Sen Hu, Xiaoyu Guo, Ye Ying, Ying Wen, Yiping Wu, Haifeng Yang. Construction of Au@Metal-organic framework for sensitive determination of creatinine in urine[J]. Journal of Innovative Optical Health Sciences, 2021, 14(4): 2141003
Received: Mar. 18, 2021
Accepted: Mar. 22, 2021
Published Online: Aug. 23, 2021
The Author Email: Wu Yiping (yipingwu@shnu.edu.cn)