Journal of Inorganic Materials, Volume. 38, Issue 7, 750(2023)
Figures & Tables(6)
![Schematic diagram of bone hierarchical structural organization (up part) and scanning electron microscope images (bottom part) of the cortical bone specimens located at human femoral diaphysis[1,11]](/Images/icon/loading.gif){kind=icon}
2. Schematic diagram of preparation process and bone forming ability of traditional calcium phosphate (CaP), whiskered calcium phosphate (wCaP) and micro-/nano-structured calcium phosphate (nwCaP) bioceramics with different surface morphologies[33]
3. Illustration of the possible molecular mechanism involved in nwCaP bioceramics induced osteogenic effect[33]
4. CD31 and EMCN staining of histological sections from the micro-/nano-structured hydroxyapatite bioceramic groups[16]
5. In vivo sequential fluorescence labeling of new bone formation inside porous nwHA bioceramics[16]
Table 1. Summary of previous work on bone formation in the micro-/nano-structured biomaterials
View tableView in ArticleTable 1. Summary of previous work on bone formation in the micro-/nano-structured biomaterials
Material Synthesis method In vitro results Animal model In vivo results Ref. β-TCP scaffolds with micro/ nano surface topography DLP printing and in situ growth crystal process Promote osteogenic differentiation of stem cells Rat skull defects Improve the bone regeneration [17] Micro/nano-scale titania fiber-like network on the surface of Ti implants One-step alkaline treatment in NaOH solution Facilitate osteogenic and angiogenic differentiation of BMSCs and endothelial cells; Suppress M1 macrophages and stimulate M2 phenotype Rabbit femur defects Induce ameliorative osseointegration [21] MNBG/PLGA bi-layered membranes Electrospinning Promote osteogenesis [24] Micro-nano rough Ti6Al4V Acid etch process Improve osteogenic differentiation of MSCs [26] HA bioceramics with submicron- to nano- topographies Sintering Maintain the conformation of BMP-2, activate the osteogenic differentiation of BMSCs Canine intramuscular implantation Process excellent bone-like apatite forming ability and outstanding osteoinductivity [28] HA with micro/nano hierarchical structures Photolithography and hydrothermal techniques Promote osteogenic differentiation of hBMSCs and angiogenic acticvity of HUVECs [41] β-TCP/CaSiO3 composite ceramics with micro/ nano-HAp the surface layer 3D bioplotting and hydrothermal treatment Upregulate the cellular differentiation of mBMSCs and gene expression of HUVECs Ectopic subcutaneous implantation at the back of rats Promote capillary formation and bone augmentation [45] PEEK/CF/n-HA ternary biocomposite with micro/ nano-topographical surface Oxygen plasma and sandblasting Promote the proliferation and differentiation of MG-63 cells Dog mandibles Boost the osseointegration between implant and bone [73] Micro/nano structural silicon nitride and PEKK composite Femtosecond laser ablation Promote osteogenic differentiation of rBMSCs; Exhibit a greater bacteriostatic activity Rabbit femur cavity defect Promote osseointegration and bone repair [75] Silicate-based bioceramic with micro-nano surfaces and hollow channels 3D printing and hydrothermal treatment Facilitate the attachment and proliferation of BMSCs Rabbit femur defects Boost the newly bone formation [80] PLLA/CS composite scaffold with micro/nano- fiber hierarchical structure 3D printing and thermally induced phase separation technology Promote cell adhesion and proliferation [87]
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Rui ZHAO, Fei MAO, Hui QIAN, Xiao YANG, Xiangdong ZHU, Xingdong ZHANG.
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Received: Sep. 30, 2022
Accepted: --
Published Online: Dec. 28, 2023
The Author Email: Hui QIAN (1000007341@ujs.edu.cn)
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