Chinese Journal of Lasers, Volume. 51, Issue 9, 0907010(2024)
Recent Advancements in Near‐Infrared Light Immunotherapy Targeted on Tumor Microenvironment
Figures & Tables(5)
![Mechanism and related immunological effects of different target NIR-PIT[10]](/Images/icon/loading.gif){kind=icon}
Fig. 4. Mechanism and related immunological effects of different target NIR-PIT[10]
Table 1. Therapeutic targets on non-tumor cells in TME
View tableTable 1. Therapeutic targets on non-tumor cells in TME
Target molecule APC Cancer Tumor model Ref. CD25 Anti-CD25-IgG-IR700， Colon cancer In vitro and in vivo ［ 32 ］Anti-CD25-F（ab'）2-IR700 Colon cancer，lung carcinoma，and prostate cancer In vitro and in vivo ［ 29 ］CD73 αCD73-IR700 Pancreatic ductal adenocarcinoma subcutaneous and breast cancer（orthotopic） In vitro and in vivo ［ 35 ］FAP Anti-FAP-IR700 Esophageal squamous cell carcinoma In vitro and in vivo ［ 44 ］Anti-FAP-α-IR700 Esophageal cancer In vitro and in vivo ［ 43 ］Integrin αvβ3 cRGD-PEG-HSA-IR700 Ovarian tumor spheroid In vitro（3D culture） ［ 50 ］IR700-PEG-PGlu-cRGDx Glioblastoma In vitro（3D culture） ［ 51 ］RGD-8PEG-IR700 Melanoma spheroid In vitro（3D culture） ［ 52 ］PDGFRβ Dimeric Z-PDGFRβ-IR700 Colorectal cancer In vitro and in vivo ［ 49 ］Podoplanin Anti PDPN-IR700 Oral cancer In vitro and in vivo ［ 53 ］VEGFR-2 DC101-IR700 Gastric cancer In vitro and in vivo ［ 48 ］VISTA Anti-VISTA-IR700 Colon cancer and lung carcinoma In vitro and in vivo ［ 37 ］
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Yingshu Cui, Yi Li, Xiaosong Li. Recent Advancements in Near‐Infrared Light Immunotherapy Targeted on Tumor Microenvironment[J]. Chinese Journal of Lasers, 2024, 51(9): 0907010
Paper Information
Category: biomedical photonics and laser medicine
Received: Nov. 13, 2023
Accepted: Jan. 18, 2024
Published Online: Apr. 11, 2024
The Author Email: Li Yi (lyin301@163.com), Li Xiaosong (Lixiaosong301@163.com)
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