Acta Optica Sinica, Volume. 35, Issue 12, 1206001(2015)
Highly Sensitive Optical Nanofiber Sensor Based on Gold Nanorod Amplification
In order to meet the requirements of high sensitivity and specificity of biomedical research, a new optical nanofiber biosensor using gold nanorods (GNR) as amplification labels is reported, based on extinction property of GNR. Optical influence of GNR attached to the surface of fiber is studied. Single GNR is successfully resolved in experiment. In this nanofiber biosensor, a sandwich assay strategy is utilized for detection. The limit of detection (LOD) of this sensor for Goat- IgG is 0.02 ng/mL in PBS, which shows a great performance in sensitivity and specificity. The biosensor, reported in this work, has the advantages of simple detection scheme, fast response time, and ease of miniaturization, which might make this biosensor a promising platform for clinical cancer diagnosis, food safety detection and environmental monitoring.
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Li Ming, Li Kaiwei, Dai Fang, Zhou Wenchao, Shu Fengfeng, Wu Yihui. Highly Sensitive Optical Nanofiber Sensor Based on Gold Nanorod Amplification[J]. Acta Optica Sinica, 2015, 35(12): 1206001
Category: Fiber Optics and Optical Communications
Received: May. 7, 2015
Accepted: --
Published Online: Dec. 10, 2015
The Author Email: Ming Li (limit_npc@hotmail.com)