Bi2Te3-based alloys are the most well-known thermoelectric materials for room-temperature applications. The existing Bi2Te3-based thermoelectric materials produced commercially are prepared by a zone melting method, resulting in highly oriented materials with high thermoelectric properties. However, the ingots produced by the zone melting method are prone to disintegration due to the weak van der Waals forces between the layers of Te atoms, leading to the poor mechanical properties and the proclivity for fracture during processing and practical applications. It is thus important to improve the mechanical properties and machinability of Bi2Te3-based materials with the excellent thermoelectric properties. This work was to prepare a n-type Bi2Te2.7Se0.3 thermoelectric material via spark plasma sintering combined with hot extrusion (SPS+HE). The parameters affacting hot extrusion process and preparation of n-type Bi2Te2.7Se0.3 materials under different process conditions were optimized, and the thermoelectric performance and mechanical properties were investigated. In addition, the machinability of the extruded Bi2Te2.7Se0.3 material was also analyzed.