Acta Optica Sinica, Volume. 38, Issue 3, 328006(2018)

Review on Plasmonic Optical Fiber Grating Biosensors

Guo Tuan*
Author Affiliations
  • [in Chinese]
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    Figures & Tables(19)
    (a) Sketch of the Kretschmann prism configuration used for plasmonic sensing; (b) its sensing principle
    Sketch of the plasmonic sensor based on fiber grating
    (a) Sketch of the uniformfiber grating and its transmission (black curve) and reflection (red curve) spectra; (b) sketch of the tilted fiber gratings and its transmission; (c) sketch of the eccentric fiber gratings and its transmission; (d) sketch of the excessively tilted fiber gratings and its transmission; (e) sketch of the long-period fiber gratings and its transmission
    Sketch of the SPR excitation around an optical fiber showing the required polarization of the electric field
    Plasmonic enhancementin gold-coated TFBG (blue curve and right-up inset) versus evanescent field TFBG in a normal bare fiber (red curve and right-down inset)
    Transmission spectra of a gold coated TFBG. (a) P-polarized incident light with SPR excited; (b) S-polarized incident light without SPR excited
    Sketch of phase mask based fiber grating inscription system
    (a) Sketch of the sputtering deposition of optical fiber coating; (b) principle of rotation coating method to obtain uniform thickness film layer; (c) microscope and scanning electron microscope view of a gold coated fiber surface
    Sketch of typical fiber optic sensor for bio-functionalization and specific measurement methods
    Scheme of fiber SPR sensors interrogation. (a) Wavelength interrogation; (b) intensity interrogation
    (a) TFBG SPR refractive index response spectral; (b) linear relationship between TFBG SPR refractive index and SRI changes
    Plasmonic TFBG cell intensity sensor[130]
    Plasmonic TFBG urinary protein sensor[127,128]
    Plasmonic TFBG glucose concentration sensor[131]
    Plasmonic TFBG electroactive microbe sensor[132]
    Plasmonic TFBG neurotransmitter sensor[133]
    Plasmonic TFBG gas sensor[40]
    (a) Picture of the packaged plasmonic fiber grating sensor; (b) biosensor inserted in a freshly biopsied tissue and its corresponding amplitude spectrum; (c) packaged sensor inserted in the operating channel of an endoscope[125]
    • Table 1. Summary of the recent study of plasmonic fiber grating biosensors

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      Table 1. Summary of the recent study of plasmonic fiber grating biosensors

      Grating architectureFunctional materialsAnalyte and sensor performancesReference
      LPFGSiO2:Au NPs modified with biotinStreptavidin detectionSensitivity: 6.88 nm·(ng·mm-2)-1Ref. [117]
      LPFGSelf-assembled Au colloids+dinitrophenyl compound (DNP)Detection of anti-DNPLOD: 950 pMRef. [118]
      TFBGAu layer+thiol-modified aptamersThrombin detection in buffer and serum solutionsLOD: 22 nMRef. [119-120]
      TFBGAu layer+SAM+anti-transferrinsTransferrin detectionLOD: 10-6 g·ml-1Ref. [121]
      TFBGAu layer+fibronectinAnalysis of cellular behavior under different stimuliRef. [122]
      TFBGAPTMS, glutaraldehyde and cysteamine thin films+Au nanocages/nanospheresBiotin detectionLOD: 11 pM (nanospheres)-8 pM (nanocages)Ref. [72]
      TFBGAu layer+boronic acidGlycoprotein detectionLOD: 2×10-5 g·ml-1Ref. [123]
      TFBGAu layer+SAM+anti-cytokeratins+BSADetection of cytokeratins 7 and 17 for lung cancer diagnosisLOD: 1 pMRef. [124-125]
      TFBGAu layer+SAM+EGFR (epidermal growth factor receptor) antibodiesDetection of epithelial cells through their EGFRLOD: 3×106 cells·ml-1Ref. [126]
      TFBGAu layer with different thicknessesDetection of proteinuria in rat urineLOD: 1.5×10-3 mg·ml-1Ref. [127]
      TFBGAu layer+SAM+aquaporin-2 antibodiesDetection of aquaporin-2 for nephrotic syndrome analysisLOD: 1.5 ng·ml-1Ref. [128]
      ETFGAu NPs+cysteamine+activated staphylococcal protein ADetection of Newcastle disease virusLOD: 25 pg·ml-1 in a 200 μL volumeRef. [109]
      FBGOligonucleotide-functionalized Au NPsDNA target sequencesRef. [129]
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    Guo Tuan. Review on Plasmonic Optical Fiber Grating Biosensors[J]. Acta Optica Sinica, 2018, 38(3): 328006

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    Paper Information

    Special Issue:

    Received: Oct. 31, 2017

    Accepted: --

    Published Online: Apr. 2, 2018

    The Author Email: Tuan Guo (tuanguo@jnu.edu.cn)

    DOI:10.3788/AOS201838.0328006

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