In order to meet the demands of areo-space electronic system for high speed high precision ADC, a radiation hardened 16-bit 80 MSPS ADC was designed. The core of 16 bit ADC was implemented with “3+4+3+3+3+3+3” pipelined structure, and the front dedicated buffer was used to reduce the kickback and improved the whole linearity of ADC. The radiation hardened technologies, such as edgeless MOS device and N+/P+ rings, were also exploited. The ADC was designed with standard 018 μm CMOS process. With the supply voltage of 33 V and 18 V, the clock frequency of 80 MHz and input frequency of 361 MHz, the power dissipation is less than 11 W, SNR is larger than 738 dB, and SFDR is larger than 88 dBFS, respectively. The SNR degrades less than 03 dB and SFDR degrades less than 1 dB after total ionizing dose irradiation of 150 krad(Si).The current increases less than 4 mA under Bi heavy ion irradiation.