Journal of Inorganic Materials, Volume. 35, Issue 2, 179(2020)

Zirconia Reinforced Trace Element Co-doped Hydroxyapatite Coating

Zhao DAI1... Ming WANG2, Shuang WANG1, Jing LI1, Xiang CHEN1, Da-Lin WANG1,* and Ying-Chun ZHU2,* |Show fewer author(s)
Author Affiliations
  • 1Hospital of Changhai, Second Military Medical University, Shanghai 200433, China
  • 2Key Laboratory of Inorganic Coating Materials, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China
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    Figures & Tables(10)
    SEM images of ZrO2 substrate (a) and as-sprayed DHA coating (b)
    SEM images (a) and elemental mapping of Ca (green) (b) and Zr (blue) (c) of 7DHA coating, and SEM images of surface (d-f) and cross sections (g-i) of DHA (d, g), 7DHA (e, h) and 3DHA (f, i)
    XRD patterns of HA and DHA powders with inset showing the enlarged parts (a), FT-IR spectra of HA and DHA powders (b), and XRD patterns of 7DHA, 5DHA and 3DHA coatings (c) with enlarged pattern of 7DHA coating (d)
    Microhardness and bond strength of coatings (a), and the section image of stretching test (b)
    OD values of cell viability test (*p<0.05)
    Fluorescence images (a-f) and cell numbers of cell adhesion test (g) (*p<0.05)
    Optical images of MC3T3-E1 cell Alizarin red S staining (a-f) and comparison of ALP activity (g) (*p<0.05)
    Osteogenesis-related genes expression with culture time
    • Table 1. Plasma spraying parameters

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      Table 1. Plasma spraying parameters

      ParameterHA/DHA coatingZrO2-DHA coatings
      Primary gas flow rate/(L‧min-1)Ar/40-41Ar/40-42
      Auxiliary gas flow rate/(L‧min-1)H2/6-7H2/8-9
      Carrier gas flow rate/(L‧min-1)Ar/6-6.5Ar/6-6.5
      Powder feed rate/(g‧min-1)1820
      Current/A650570
      Gun transverse speed/(mm‧s-1)500500
      Standoff distance/mm100100
    • Table 2. Sequence of primers

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      Table 2. Sequence of primers

      GeneSequence
      AlpF: 5-AACGTGGCCAAGAACATCATCA-3R: 5-TGTCCATCTCCAGCCGTGTC-3
      Col-IF: 5-CCAGAAGAACTGGTACATCAGCAA-3R: 5-CGCCATACTCGAACTGGAATC-3
      GapdhF: 5-GGCATTGCTCTCAATGACAA-3R: 5-TGTGAGGGAGATGCTCAGTG-3
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    Zhao DAI, Ming WANG, Shuang WANG, Jing LI, Xiang CHEN, Da-Lin WANG, Ying-Chun ZHU. Zirconia Reinforced Trace Element Co-doped Hydroxyapatite Coating[J]. Journal of Inorganic Materials, 2020, 35(2): 179

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    Paper Information

    Category: RESEARCH PAPER

    Received: Jan. 27, 2019

    Accepted: --

    Published Online: Jan. 27, 2021

    The Author Email: WANG Da-Lin (wang_dento@163.com), ZHU Ying-Chun (yzhu@mail.sic.ac.cn)

    DOI:10.15541/jim20190053

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