Journal of Inorganic Materials, Volume. 35, Issue 2, 179(2020)

Zirconia Reinforced Trace Element Co-doped Hydroxyapatite Coating

Zhao DAI1... Ming WANG2, Shuang WANG1, Jing LI1, Xiang CHEN1, Da-Lin WANG1,* and Ying-Chun ZHU2,* |Show fewer author(s)
Author Affiliations
  • 1Hospital of Changhai, Second Military Medical University, Shanghai 200433, China
  • 2Key Laboratory of Inorganic Coating Materials, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China
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    Zirconia is a kind of prospective hard tissue implant materials, which possesses superior mechanical properties and excellent biocompatibilities. To promote the stable osseointegration between Zirconia implants and tissue, zirconia-toughened trace Sr-, Si- and F- co-doped hydroxyapatite (ZrO2-DHA) was coated by plasma spraying on zirconia. The phase composition and structure of coatings were characterized, and the mechanical properties and in vitro biological properties were investigated. The results show that co-doping of trace Sr, Si and F enhances the biological properties of coatings on adhesion and differentiation of osteoblasts through the signal transduction pathway of osteogenic differentiation. All of ZrO2-DHA coatings promote the cell viability and gene expression in osteogenic differentiation of MC3T3-E1. On the 7th day of cell culture, the relative expression levels of Alp and Col-I in the ZrO2-DHA coating containing 70% DHA (7DHA) were about 2.8 times and 2.3 times higher than those in the ZrO2 substrate group, respectively. Mechanical properties of ZrO2-DHA coatings are improved with the increment of zirconia ratio. Hardness of DHA coating and 7DHA coating are 250.8 and 313.8HV respectively and their bond strength are 25.1 and 31.8 MPa, respectively. 7DHA coatings with network structure possess both excellent mechanical and biological performance for the implant coating application.

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    Zhao DAI, Ming WANG, Shuang WANG, Jing LI, Xiang CHEN, Da-Lin WANG, Ying-Chun ZHU. Zirconia Reinforced Trace Element Co-doped Hydroxyapatite Coating[J]. Journal of Inorganic Materials, 2020, 35(2): 179

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    Paper Information

    Category: RESEARCH PAPER

    Received: Jan. 27, 2019

    Accepted: --

    Published Online: Jan. 27, 2021

    The Author Email: WANG Da-Lin (wang_dento@163.com), ZHU Ying-Chun (yzhu@mail.sic.ac.cn)

    DOI:10.15541/jim20190053

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