Journal of Inorganic Materials, Volume. 38, Issue 1, 32(2023)

Functional Nanomaterials for Electrochemical SRAS-CoV-2 Biosensors: a Review

Yao LIU1...2, Xunhai YOU1,3, Bing ZHAO1,3, Xiaoying LUO4,*, and Xing CHEN1,23,* |Show fewer author(s)
Author Affiliations
  • 11. Institute of Industry and Equipment Technology, Hefei University of Technology, Hefei 230009, China
  • 22. School of Resources and Environmental Engineering, Hefei University of Technology, Hefei 230009, China
  • 33. School of Materials Science and Engineering, Hefei University of Technology, Hefei 230009, China
  • 44. State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200032, China
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    Figures & Tables(8)
    Structure of SARS-CoV-2
    Electrochemical biosensors based on gold nanomaterials for the detection of SARS-CoV-2
    Metal oxide nanomaterials used in electrochemical sensors to detect SARS-CoV-2
    Electrochemical biosensors based on carbon nanomaterials for the detection of SARS-CoV-2
    Graphene nanocomposites used in electrochemical sensors to detect SARS-CoV-2
    Paper-based electrochemical biosensor for diagnosing COVID-19[59]
    • Table 1. Comparison of detection methods for SARS-CoV-2 detection

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      Table 1. Comparison of detection methods for SARS-CoV-2 detection

      Detection methodTime/hAdvantageDisadvantage
      Reverse transcrition-polymerase chain reaction (RT-PCR)4-6High sensitivity and reliabilityLow costVersatility in sample typesSpecial instrumentsComplicated operationTime-consuming
      Enzyme linked immunosorbent assay (ELISA)1-3Simple operationLow priceFast detectionLow specificitySuitability only for the late stage of the disease
      Surface-enhancedRaman spectroscopy (SERS)<1Simple constructionGood repeatabilitySpecialized SERS active substrates
      Electrochemical detection<1Lower costSimpler constructionHigher specificityRelatively lower sensitivityLower clinical trial accuracy
    • Table 2. Comparison of SARS-CoV-2 detection performance of electrochemical sensors constructed from different nanomaterials

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      Table 2. Comparison of SARS-CoV-2 detection performance of electrochemical sensors constructed from different nanomaterials

      MaterialMethodDetecting objectLimit of detectionRef.
      AuNPsi-tRNA or cDNAN/A[46]
      Gold nanoneedleSWVS geneOrf1ab gene5.0×10-18 g·μL-16.8×10-18 g·μL-1[47]
      AuNPs/PEDOTEISPositive and negative serum sampleN/A[48]
      Au@Fe3O4/rGODPVRNA3×10-18 mol·L-1[6]
      Co-TiO2 nanotubesi-tRBD7×10-10 mol·L-1[49]
      ZnO/rGOEISN protein antigens2×10-14 g·mL-1[5]
      Carbon black nanomaterialLSVS proteinN protein1.9×10-8 g·mL-18×10-9 g·mL-1[50]
      Laser-engraved grapheneLSVN-protein,S1-IgMS1-IgGC-reactive proteinN/A[61]
      AuNPs/rGOEISS1 proteinRBD antibodies2.8×10-15 mol·L-11.69×10-14 mol·L-1[55]
      SiO2@UiO-66EISS protein1×10-13 g·mL-1[57]
      GOSWVIgGIgM9.6×10-10 g·mL-11.4×10-10 g·mL-1[59]
      Au@Pt/MIL-5(Al)DPVN-protein8.33×10-12 g·mL-1[58]
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    Yao LIU, Xunhai YOU, Bing ZHAO, Xiaoying LUO, Xing CHEN. Functional Nanomaterials for Electrochemical SRAS-CoV-2 Biosensors: a Review[J]. Journal of Inorganic Materials, 2023, 38(1): 32

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    Paper Information

    Category:

    Received: Jul. 4, 2022

    Accepted: --

    Published Online: Sep. 25, 2023

    The Author Email: LUO Xiaoying (luoxy@shsci.org), CHEN Xing (xingchen@hfut.edu.cn)

    DOI:10.15541/jim20220384

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