Opto-Electronic Advances, Volume. 4, Issue 8, 200081-1(2021)

Flexible fiber-laser ultrasound sensor for multiscale photoacoustic imaging

Bai-Ou Guan*... Long Jin, Jun Ma, Yizhi Liang and Xue Bai |Show fewer author(s)
Author Affiliations
  • Guangdong Provincial Key Laboratory of Fiber Optic Sensing and Communications, Institute of Photonics Technology, Jinan University, Guangzhou 511443, China
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    Figures & Tables(9)
    (a) The calculated deformations of the fiber surrounded by water in response to plane ultrasound waves. Left: TR21 mode at 22 MHz. Right: TR22 mode at 39 MHz. Arrows: local displacement. (b) Analogous model of a spring-mass oscillator. (c) Schematic of the phase cancelation effect. (d) Frequency responses with different source-to-fiber distances.
    (a,d) Schematics of a straight sensor and curved (bending radius R=30 mm) sensor subjected to a point ultrasound source. The dashed curves show the acoustic phase variation along the fiber. (b–c) Calculated spatial sensitivities of a straight sensor in the x-z and x-y planes. (e–f) Calculated spatial sensitivities of a curved sensor in the x-z and y-z planes. Figure reproduced with permission from ref.29, Optical Society of America.
    (a) Schematic of ultrasound detection by using a fiber-laser sensor. (b) Unperturbed and ultrasonically perturbed beat signal output from the sensor. Figure reproduced with permission from ref.30, under a Creative Commons Attribution 4.0 International License.
    (a) Temporal and (b) frequency response of the sensor. (c) Measured NEP as a function of input power at the photodetector. (d) Stability test result by continuously measuring the photoacoustic signals from two discrete absorbers over 30 min. Figure reproduced with permission from ref.31, Optical Society of America.
    (a) Schematic of a fiber-based PAM apparatus. (b) Schematic (left) and result (right) of the field-of-view measurement. (c) PAM result of a mouse ear that contains branches of blood vessels and capillaries. (d) Three consecutive snapshots showing the blood flow in the mouse ear. (e) Hemoglobin concentration image of a mouse brain obtained with a 532 nm pulse laser. (f) Oxygen saturation images enabled by a dual-wavelength laser source33, 34.
    (a) The optical signal duplication system. The ultrasonically modulated laser light is duplicated into 8 copies. (b) Demodulated ultrasound signals of the 8 copies. (c) B-scan signals before and after signal averaging, showing a 3.5 dB reduction in the background noise. (d) In vivo PAM results before and after signal averaging. The visibility has been effectively enhanced by the signal averaging method. Figure reproduced with permission from ref.35, Optical Society of America.
    (a) Schematic of a rotary-scanning PACT with the fiber laser sensor. Photoacoustic images of (b) a zebrafish and (c) a mouse brain. SB: swim bladder; SC: spinal cord; AF: anal fin; CV: cortical vessels; SSS: superior sagittal sinus; ICV: inferior cerebral vein. Figure reproduced with permission from ref.29, Optical Society of America.
    (a) Photograph of the holder for adjusting the bending curvature of the sensor. (b) Schematic of the multidepth PACT. (c) Photoacoustic images of human hairs at different depths in the x-z plane. (d) In vivo photoacoustic image of the abdominal subcutaneous vasculature of a rat. (e) Photograph of the rat with the fur removed before imaging. The red dashed box in (e) corresponds to the green box in (d). The yellow dashed line in (e) corresponds to the white dashed line in (d). Figure reproduced with permission from ref.36, AIP Publishing.
    • Table 1. Comparison of piezoelectric and optical ultrasound transducers.

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      Table 1. Comparison of piezoelectric and optical ultrasound transducers.

      Sensor typeMaterialBandwidth (MHz) NEP (mPa·Hz–1/2) Demodulation method Common application
      N.R.: not reported.
      Piezoelectric transducer Spherically focused (Olympus V214) Piezoceramic50 MHz0.2VoltagePAM
      Needle (Precision acoustics)PVDFN.R.14.4VoltageN.R.
      Optical ultrasound sensors Micro-ring17Polystyrene3505.61CW interferometryPAM
      Fabry-PérotPET/Parylene C SU8182044.7CW interferometryPACT
      Epoxy122.81.6CW interferometryPAM
      π-FBGSilica151625CW interferometryPAM
      Present sensorSilica1810.6Beat signalPAM/PACT
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    Bai-Ou Guan, Long Jin, Jun Ma, Yizhi Liang, Xue Bai. Flexible fiber-laser ultrasound sensor for multiscale photoacoustic imaging[J]. Opto-Electronic Advances, 2021, 4(8): 200081-1

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    Paper Information

    Category: Review

    Received: Nov. 21, 2020

    Accepted: Dec. 30, 2020

    Published Online: Sep. 24, 2021

    The Author Email: Guan Bai-Ou (tguanbo@jnu.edu.cn)

    DOI:10.29026/oea.2021.200081

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