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Journal of Inorganic Materials, Volume. 35, Issue 11, 1277(2020)

Injectable Magnetic Liquid-solid Phase Transition Material for MR Imaging and Low-temperature Magnetocaloric Therapy of Osteosarcoma

Dong XU1...2, Yufang ZHU1,2, Yuanyi ZHENG3, Yu LUO2,4,* and Hangrong CHEN2,* |Show fewer author(s)
Author Affiliations
  • 1School of Materials Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China
  • 2Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China
  • 3Shanghai Institute of Ultrasound in Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China;
  • 4School of Chemical Science and Engineering, Tongji University, Shanghai 200092, China
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    TEM images of superparamagnetic Fe3O4 nanoparticles (a), XRD patterns (b), XPS spectra (c), r2 relaxation rate (d),saturation magnetization (e), and temperature rise curves of different Fe concentrations in an alternating magnetic field (f)
    1. TEM images of superparamagnetic Fe3O4 nanoparticles (a), XRD patterns (b), XPS spectra (c), r2 relaxation rate (d),saturation magnetization (e), and temperature rise curves of different Fe concentrations in an alternating magnetic field (f)

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    Digital photo of Fe3O4 dispersed in PLGA liquid to obtain a homogeneous fluid (a); Digital photo of PLGA / Fe3O4 fluid sucked with a 1 mL syringe (b); Digital photo of liquid-solid phase transition of PLGA / Fe3O4 fluid driven into water with a syringe (c)
    2. Digital photo of Fe3O4 dispersed in PLGA liquid to obtain a homogeneous fluid (a); Digital photo of PLGA / Fe3O4 fluid sucked with a 1 mL syringe (b); Digital photo of liquid-solid phase transition of PLGA / Fe3O4 fluid driven into water with a syringe (c)

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    SEM image of PLGA/Fe3O4 (PF) composite (a), with its corresponding EDX spectrum (b), and different elements mapping (c)
    3. SEM image of PLGA/Fe3O4 (PF) composite (a), with its corresponding EDX spectrum (b), and different elements mapping (c)

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    Temperature rise of PLGA/Fe3O4 composite (PF) in AMF (a), cytotoxicity (b) and in vitro T2-weighted MR imaging (c), and the cytocompatibility of the inhibitor EGCG under simulated magnetocalormic temperature rise (43 ℃, d)
    4. Temperature rise of PLGA/Fe3O4 composite (PF) in AMF (a), cytotoxicity (b) and in vitro T2-weighted MR imaging (c), and the cytocompatibility of the inhibitor EGCG under simulated magnetocalormic temperature rise (43 ℃, d)

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    Therapeutic effects of different groups on MG-63 cells under AMF
    5. Therapeutic effects of different groups on MG-63 cells under AMF

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    Dong XU, Yufang ZHU, Yuanyi ZHENG, Yu LUO, Hangrong CHEN. Injectable Magnetic Liquid-solid Phase Transition Material for MR Imaging and Low-temperature Magnetocaloric Therapy of Osteosarcoma[J]. Journal of Inorganic Materials, 2020, 35(11): 1277

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    Paper Information

    Category: RESEARCH PAPER

    Received: Jan. 9, 2020

    Accepted: --

    Published Online: Mar. 10, 2021

    The Author Email: LUO Yu (yuluo@tongji.edu.cn), CHEN Hangrong (hrchen@mail.sic.ac.cn)

    DOI:10.15541/jim20200016

    Topics

    laser devices and laser physics
    Lasers and Laser Optics
    Laser physics
    laser manufacturing
    Instrumentation, Measurement and Metrology