Journal of Radiation Research and Radiation Processing, Volume. 41, Issue 3, 030303(2023)
PARPi increases radiotherapy sensitivity of esophageal squamous cell carcinoma by inhibiting XRCC1 expression
Figures & Tables(8)
Fig. 1. Expression of XRCC1 in ESCC (SP method, ×200): (a) XRCC1 positive, with cytoplasm and nuclei, yellowish-brown particles; (b) XRCC1 negative expression
Fig. 2. Expression of PARP-1 in ESCC (SP method, ×200): (a) PARP-1 positive, with cytoplasm and nuclei, yellow-brown granules; (b) PARP-1 negative expression
Fig. 3. Curves of viability of ECA109 cell treated with different concentrations of AZD2281 for 24 h and 48 h
Table 1. Number of colonies formed in each group
View tableView in ArticleTable 1. Number of colonies formed in each group
剂量 / Gy
Dose
接种数
Number of cells inoculated
放疗组集落形成数
Number of colony formation in
radiotherapy group
联合组集落形成数
Number of colony formation in
combined treatment group
0 250 225 218 2 500 196 162 4 1 000 231 139 6 1 500 189 77
Table 2. Parameters obtained by fitting a single-hit multi-target model
View tableView in ArticleTable 2. Parameters obtained by fitting a single-hit multi-target model
组别 Group k n D0 Dq SER 放疗组 Radiation group 0.246 0.610 4.065 -2.009 1.744 联合组 Combined treatment group 0.429 0.845 2.331 -0.393
Table 3. XRCC1mRNA relative expression in ECA109 cells of each group
View tableView in ArticleTable 3. XRCC1mRNA relative expression in ECA109 cells of each group
组别
Group
对照组
Contl group
药物组
PARPi treated group
辐照组
Radiation group
联合组
Combined treatment group
XRCC1mRNA表达量
Expression level of XRCC1 mRNA
1.218 0.941 1.682 0.648 XRCC1mRNA相对表达量
Relative expression level of XRCC1 mRNA
1 0.772 1.381 0.532
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Yiping LI, Yufei ZHANG, Guangzhi SUN, Yunyao YE, Xiaozhou SHEN, Gaohua HAN. PARPi increases radiotherapy sensitivity of esophageal squamous cell carcinoma by inhibiting XRCC1 expression[J]. Journal of Radiation Research and Radiation Processing, 2023, 41(3): 030303
Paper Information
Category: Research Articles
Received: Nov. 9, 2022
Accepted: Jan. 31, 2023
Published Online: Jul. 24, 2023
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