Acta Optica Sinica, Volume. 40, Issue 4, 430001(2020)

Detection of Cerebral Ischemia Based on Terahertz Time-Domain Spectroscopy

Wang Yuye1,2, Sun Zhongcheng1,2, Xu Degang1,2、*, Jiang Zhinan1,2, Mu Ning3, Yang Chuanyan3, Chen Tunan3, Feng Hua3, and Yao Jianquan1,2
Author Affiliations
  • 1School of Precision Instruments and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China
  • 2Key Laboratory of Optoelectronics Information Technology (Ministry of Education), Tianjin University, Tianjin 300072, China
  • 3Department of Neurosurgery, Southwest Hospital, Army Medical University, Chongqing 400038, China
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    Figures & Tables(9)
    Schematic diagram of the transmissive terahertz time-domain spectroscopy system
    Results of TTC staining of brain tissues at different ischemia time. (a) 0 h; (b) 2 h; (c) 4 h; (d) 6 h; (e) 24 h
    Preparation of fresh brain ischemic tissue sections
    Terahertz wave properties of the left and right brains of fresh cerebral ischemic tissue at 4 h. (a) Time domain spectrum; (b) frequency domain spectrum; (c) average absorption coefficient; (d) average refractive index
    Relative difference of terahertz wave absorption coefficients between left and right brains in fresh brain tissue at different ischemia time
    Changes in physical properties of brain tissue at different ischemia time. (a) Water content of left and right brains; (b) cell density of left brain
    Preparation of paraffin-embedded cerebral ischemic tissue
    Terahertz wave absorption characteristics of paraffin-embedded cerebral ischemic tissue. (a) Absorption coefficient of left and right brains in paraffin-embedded cerebral ischemic tissue at 4 h; (b) relative difference of terahertz wave absorption coefficients in paraffin-embedded brain tissue between left and right brains at different ischemic time
    Normalized relative difference terahertz wave absorption coefficients between left and right brains and cell density of left brain
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    Wang Yuye, Sun Zhongcheng, Xu Degang, Jiang Zhinan, Mu Ning, Yang Chuanyan, Chen Tunan, Feng Hua, Yao Jianquan. Detection of Cerebral Ischemia Based on Terahertz Time-Domain Spectroscopy[J]. Acta Optica Sinica, 2020, 40(4): 430001

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    Paper Information

    Category: Spectroscopy

    Received: Oct. 14, 2019

    Accepted: --

    Published Online: Feb. 11, 2020

    The Author Email: Degang Xu (xudegang@tju.edu.cn)

    DOI:10.3788/AOS202040.0430001

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