A drive circuit for solid-state high-voltage Marx pulser generator is designed, and the output side of the drive circuit adopts energy storage capacitor and P-N-MOS structure, which can complete the synchronization, fast turning on and turnin off control of the power MOSFET in the power circuit of the solid-state pulse generator, and has the functions of dead-time adjustment and negative voltage bias. In addition, the drive circuit is combined with the scheme of reverse wiring on the secondary side of the core-piercing magnetic ring to realize the control of two power MOSFETs of charging and discharging in the power loop using the same signal. Experiments show that the solid-state Marx pulse generator using this drive circuit can output a pulse square wave with a stable amplitude of 24 kV, and the output pulse width can be freely adjusted between 300 ns and 10 μs, and the rising and falling edges are within 40 ns.