Journal of Inorganic Materials, Volume. 35, Issue 2, 250(2020)

Aluminum Hydroxide Nanosheets with Structure-dependent Storage and Transportation toward Cancer Chemotherapy

Xia LI1... Mohamed A SHENASHEN1, Moataz MEKAWY1, Akiyoshi TANIGUCHI2,3, and Sherif A EI-SAFTY13,* |Show fewer author(s)
Author Affiliations
  • 1Research Center for Functional Materials, National Institute for Materials Science, Ibaraki 305-0047, Japan
  • 2Cellular Functional Nanomaterials Group, Research Center for Functional Materials, National Institute for Materials Science, Tsukuba, Ibaraki 305-0044, Japan
  • 3Engineering and Advanced Manufacturing, University of Sunderland, Sunderland, United Kingdom
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    Figures & Tables(5)
    (A) Transmission electron micrograph images of Al-L (a) and Al-H (b, c); (B) Atomic force microscopy image of Al-H; (C) N2 sorption isotherms and pore size distribution curves of the samples; (D) XRD patterns of the samples; (E) The release curves of Dox for the AlOOH NSs
    (A) Confocal laser scanning micrographs of cellular uptake of Al-H/Dox samples by DU145 cells after coculture for 0.5 (a), 2.5 (b) and 24 h (c); (B) Histogram and (C) quantitative results of Dox cellular uptake efficiency (E%) by DU145 cells incubated for 2 h with (a) control, (b) Al-L/Dox at 5 μg/mL of particles, (c) Al-H/Dox at 5 μg/mL of particles, and (d) free Dox with an equivalent amount of Dox loaded onto Al-H/Dox samples
    Percentage of apoptosis and necrosis in DU145 cells treated with control (A), Al-L/Dox at 25 μg/mL (B), or Al-H/Dox at 25 μg/mL (C) for 1 d; Free Dox with an equivalent amount of Dox released from Al-H/Dox after 1 d at pH 5 was used as contrast (D)
    Blood biochemistry analysis (A-E) of mice after intravenous administration with Al-H (n=3)
    Formation of AlOOH NSs, loading of chemotherapy drugs onto NSs, and intravenous injection of the as-prepared NSs
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    Xia LI, Mohamed A SHENASHEN, Moataz MEKAWY, Akiyoshi TANIGUCHI, Sherif A EI-SAFTY. Aluminum Hydroxide Nanosheets with Structure-dependent Storage and Transportation toward Cancer Chemotherapy[J]. Journal of Inorganic Materials, 2020, 35(2): 250

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    Paper Information

    Category: RESEARCH LETTERS

    Received: Jan. 25, 2019

    Accepted: --

    Published Online: Jan. 27, 2021

    The Author Email: EI-SAFTY Sherif A (Sherif.ELSAFETY@nims.go.jp)

    DOI:10.15541/jim20190052

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